Microfluidic Device Segmentation for Storable Sample Archiving
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Solution Overview
Problem
Current biological sample analysis methods require laboratory environments and trained personnel, leading to time delays, increased costs, and limited accessibility for medical diagnostics and forensic analysis.
Innovation Solution
A microfluidic device system that allows for the analysis of biological samples at various locations with lower-trained personnel, using a disposable, single-use cartridge that performs sample preparation, amplification, and electrophoresis, enabling faster and more cost-effective analysis by detaching a storable sample section for archiving.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a permanent waste chamber is used to receive waste fluid sample, then the device structure is simple, but the sample cannot be stored for later analysis
Solution Approach 1:
The microfluidic device is divided into a main body and a detachable receiving location section. The receiving location is provided in a separate section that can be detached from the microfluidic device main body, allowing the sample to be stored in the detachable section while keeping the main device structure relatively simple.
Solution Approach 2:
The receiving location is extracted as a separate detachable section from the main microfluidic device. This section can be removed and used independently for sample storage, separating the storage function from the analysis function.
2Measurement precision
If laboratory environment and trained personnel are used for biological sample analysis, then analysis accuracy is ensured, but time delays and increased costs occur
Solution Approach 1:
The microfluidic device is designed to perform sample preparation, amplification, and analysis automatically without requiring trained personnel to manually perform each step. The device guides users through simple operations while automating complex processes, enabling non-experts to conduct accurate biological analyses.
Solution Approach 2:
The microfluidic device integrates multiple functions including sample preparation, PCR amplification, and electrophoresis analysis into a single portable unit, eliminating the need for separate laboratory equipment and personnel for each function.
3Adaptability or versatility
If a detachable receiving location section is added to store samples, then sample archiving capability is provided, but device complexity increases
Solution Approach 1:
The device is segmented into a main body and a detachable receiving location section. The receiving location is provided in a section that can be detached from the microfluidic device, allowing sample archiving while keeping the main device structure manageable.
Solution Approach 2:
The receiving location section is designed to attach to and integrate with the main microfluidic device during operation, then detach for storage. The section contains integrated components including channels, chambers, and sealing mechanisms that nest together in a compact configuration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Facilitates rapid, cost-effective, and accessible analysis of biological samples, reducing the need for laboratory settings and trained personnel, while ensuring reliable results through efficient sample processing and archiving.
Implementation Method 1
conveying at least a part of the sample to a receiving location
Implementation Method 2
The one or more processes and/or one or more reactions may include one or more of: cell lysis
Implementation Method 3
passing the sample through one or more channels and/or chambers to mix the sample with one or more fluids and/or solids
Implementation Method 4
increasing the temperature of the sample and/or a mixture including the sample
Implementation Method 5
holding the sample and/or a mixture including the sample in a chamber for a period of time
Implementation Method 6
washing at least another part of the sample from the chamber where the at least a part of the sample is retained
Implementation Method 7
retaining at least a part of the sample in a chamber, preferably on a surface of one or more solids, preferably using a magnetic field
Implementation Method 8
eluting the retained part of the sample into a fluid
Implementation Method 9
selective separation of denaturation
Data Source
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AI summary
A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.