Microfluidic Microparticle Production With Carrier-Fluid Droplet Stabilization

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Solution Overview

Problem

Existing microparticle production systems using microfluidics face challenges in stable transport of droplets without agglomeration or destruction, particularly in mass production scenarios where multiple devices are connected in parallel.

Innovation Solution

A microparticle producing system and method that incorporates a carrier fluid source and controller to stabilize droplet transport through controlled flow rates and velocities, ensuring laminar flow by combining carrier fluids with discharge fluids in a controlled manner.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If multiple microfluidic devices are arranged in parallel for mass production, then productivity is improved, but droplet transport stability deteriorates causing agglomeration and destruction

Engineering Contradiction:
Improvemass production capabilityVSAvoiddroplet transport stability
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

A carrier fluid is introduced as an intermediary substance to transport droplets through the transport channel. The carrier fluid provides a stable medium that prevents droplet agglomeration and destruction during transport, enabling reliable operation in parallel mass production configurations

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The system separates droplet production and transport functions into distinct modules. Multiple droplet producing chips can be connected in parallel to a common transport channel, allowing independent production units to operate simultaneously while maintaining stable transport through the carrier fluid medium

Inventive Principle:
Principle #1Segmentation

2Productivity

If carrier fluid flow rate is increased to improve transport efficiency, then productivity is improved, but droplet stability deteriorates causing destruction

Engineering Contradiction:
Improvetransport efficiencyVSAvoiddroplet integrity
Core Design Contradiction:
ProductivityVSManufacturing precision

Solution Approach 1:

The system optimizes the flow rate parameter of the carrier fluid to achieve a balance between transport efficiency and droplet stability. By carefully controlling the flow rate within specific ranges, the system maintains laminar flow that transports droplets effectively while preventing shear forces that would cause droplet destruction

Inventive Principle:
Principle #35Parameter changes

3Productivity

If microfluidic device scale is increased for mass production, then productivity is improved, but manufacturing precision deteriorates

Engineering Contradiction:
Improveproduction scaleVSAvoidsurface properties and diameter control
Core Design Contradiction:
ProductivityVSManufacturing precision

Solution Approach 1:

The system maintains small-scale high-precision droplet producing chips while connecting multiple units in parallel for mass production. Each chip retains its precise manufacturing capabilities for controlling surface properties and diameter, while the overall system achieves high throughput through parallel operation

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The carrier fluid acts as a mediator that allows precise control of droplet parameters to be maintained even as production scale increases. The carrier fluid ensures that droplets produced with high precision in individual chips maintain their properties during transport and combination in the larger system

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables effective microparticle production by stabilizing droplet transport, preventing agglomeration and destruction, thereby facilitating efficient mass production using microfluidics.

Implementation Method 1

allowing a flow rate of the combined fluid larger than that of the discharge fluid

Methodology Applied
Scientific EffectLaminar flow: Laminar Flow

Data Source

PatentEP4101531B1System for producing microparticles, comprising carrier fluid, and method for controlling same
Publication Date: 2025.08.06 INVENTAGE LAB INC
  • EP4101531B1 patent drawingFigure 1
  • EP4101531B1 patent drawingFigure 2
  • EP4101531B1 patent drawingFigure 3

AI summary

The present invention disclosed herein relates to a microparticle producing system using microfluidics and a controlling method thereof, and specifically, to a microparticle producing system that may stably transport droplets produced using microfluidics without agglomeration or destruction, compared to the conventional art, and a method of controlling the microparticle producing system to transport the droplets more stably in the microparticle producing system. By the microparticle producing system and the controlling method thereof, which are disclosed herein, droplets produced by the microparticle producing system using microfluidics may be stably transported without agglomeration or destruction, resulting in more effective microparticle production.