Microfluidic Chip Gas Jetting for Particle Sorting
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Solution Overview
Problem
Existing micro-fluidic chips for sorting and collecting micro-particles, such as cells and micro-beads, often cause damage to the particles due to the need for strong active forces to change their direction, leading to reduced analysis accuracy, and pose bio-hazard risks due to aerosol generation during sorting in open systems.
Innovation Solution
A micro-fluidic chip with a gas jetting section that controls the movement of micro-particles by jetting gas towards the liquid, allowing for accurate and safe direction control without damaging the particles, and includes a cavity zone with branch zones to guide droplets into selected areas, preventing aerosol formation and contamination.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a strong active force is applied to change the moving direction of micro-particles, then the direction control accuracy is improved, but the micro-particles are damaged
Solution Approach 1:
The patent applies pneumatic pressure through a gas introduction channel to control the movement direction of micro-particles. By introducing gas at controlled positions and timings, the system achieves accurate directional control without requiring strong active forces that would damage the particles. The gas pressure creates flow patterns that guide particles along desired paths while maintaining their structural integrity.
2Productivity
If the moving direction of micro-particles is changed in a continuously flowing liquid, then the sorting function is achieved, but the upstream flow is disturbed and analysis accuracy is lowered
Solution Approach 1:
The patent implements local quality by introducing gas at specific localized positions within the channel rather than uniformly throughout. The gas introduction channel is positioned to create flow modifications only in the downstream region where particle redirection is needed. This localized approach achieves sorting functionality without disturbing the upstream flow conditions, thereby maintaining analysis accuracy.
3Productivity
If an electric field or magnetic field is used to control micro-particle movement, then the sorting capability is improved, but the device configuration becomes complicated
Solution Approach 1:
The patent replaces complex electric or magnetic field systems with a simpler pneumatic system. By using a gas introduction channel connected to a gas source, the system achieves sorting capability through pressure-driven flow control. This pneumatic approach significantly simplifies the device configuration compared to electromagnetic systems, while maintaining effective sorting functionality.
4Productivity
If micro-particles are sorted in atmospheric air using the Jet in Air system, then the sorting speed is improved, but aerosol is generated causing contamination and bio-hazard risks
Solution Approach 1:
The patent creates a controlled liquid-phase environment within the microfluidic channel to replace the atmospheric air setting. By maintaining particles suspended in liquid throughout the sorting process and only exposing them to gas briefly at the collection stage, the system achieves fast sorting speeds while preventing aerosol generation. The liquid environment contains particles securely, eliminating contamination and bio-hazard risks associated with aerosolization.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables quick, accurate, and safe control of micro-particle movement within an enclosed system, minimizing particle damage and preventing bio-hazard contamination, while maintaining high sorting accuracy and efficiency.
Implementation Method 1
a gas jetting section configured to jet a gas toward the micro-particle-containing liquid ejected from the channel
Data Source
AI summary
A micro-fluidic chip including a channel through which a liquid containing micro-particles flows, and a gas jetting section configured to jet a gas toward the micro-particle-containing liquid ejected from the channel is provided.


