Microfluidic Device Lamination with Gas-Lift and Elastic Layers

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Solution Overview

Problem

Existing microfluidic devices face challenges in achieving a uniform and defined connection between a film and a carrier while preventing undesired adhesion in non-connection areas, which affects the three-dimensional shaping and functionality of the devices.

Innovation Solution

A method involving a laminating device that uses gas injection or ventilation to lift the film in non-bonding areas during lamination, and the use of elastic intermediate layers to equalize contact pressure, ensuring a uniform connection and preventing adhesion, while the film is shaped three-dimensionally using heat and pressure.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Strength

If the film is pressed onto the carrier under heat and pressure to achieve bonding, then connection strength is improved, but undesired adhesion occurs in non-connection areas

Engineering Contradiction:
Improveconnection strengthVSAvoidundesired adhesion
Core Design Contradiction:
StrengthVSObject-generated harmful factors

Solution Approach 1:

The mask is divided into bonding areas (solid portions) and non-bonding areas (openings), allowing selective bonding only in specific regions. This segmentation enables the film to bond where needed while remaining unbonded in non-connection areas, resolving the contradiction between achieving strong connections and preventing undesired adhesion.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Different regions of the mask have different properties: solid areas provide bonding contact while openings provide no contact. This local differentiation allows the film to exhibit different bonding states in different areas, achieving strong bonding where required and preventing adhesion where not desired.

Inventive Principle:
Principle #3Local quality

2Manufacturing precision

If the film is pressed uniformly onto the carrier, then bonding coverage is improved, but three-dimensional shaping in non-connection areas is hindered

Engineering Contradiction:
Improvebonding uniformityVSAvoidthree-dimensional shaping
Core Design Contradiction:
Manufacturing precisionVSShape

Solution Approach 1:

The mask structure segments the pressing surface into bonding zones and non-bonding zones. In non-bonding areas (openings), the film is not pressed onto the carrier, allowing it to bulge and form three-dimensional shapes while maintaining uniform bonding in the solid areas.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The film transitions from a two-dimensional planar state in bonding areas to a three-dimensional bulged state in non-bonding areas. The mask openings enable this dimensional change by providing space for the film to deform vertically without being constrained by carrier contact.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

3Shape

If gas is blown to lift the film in non-bonding areas, then three-dimensional shaping is improved, but adhesion prevention may be compromised

Engineering Contradiction:
Improvethree-dimensional shapingVSAvoidadhesion prevention
Core Design Contradiction:
ShapeVSReliability

Solution Approach 1:

The mask is designed with openings in non-bonding areas before the bonding process begins. This preliminary structural arrangement prevents adhesion by design rather than requiring active gas blowing during the process. The openings ensure that no adhesion can occur in these areas regardless of gas pressure.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The mask acts as an intermediary between the film and carrier, using its opening structure to control where bonding occurs. The mask physically prevents the film from contacting the carrier in non-bonding areas, serving as a mediator that eliminates the need for active adhesion prevention measures like gas blowing.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach simplifies the production of microfluidic devices with uniform connections, prevents adhesion in non-connection areas, and enhances the three-dimensional shaping of chamber walls, leading to improved microfluidic systems for fluid manipulation and handling.

Implementation Method 1

The film is laminated onto the carrier in particular under the action of pressure and/or heat and in particular includes what is known as heat sealing

Methodology Applied
Scientific EffectHeat sealing: Heating

Implementation Method 2

blowing the film in the non-bonding area during lamination or bonding by carrier-side gas injection is raised

Methodology Applied
Scientific EffectGas injection: Pressure Gradient

Implementation Method 3

the connection of the film to the carrier by means of an elastic intermediate layer which is placed between the film and an associated thermode and/or between the carrier and an associated holder

Methodology Applied
Scientific EffectElasticity: Elasticity

Data Source

PatentEP2611594B1Method of making a microfluidic device and related laminating apparatus
Publication Date: 2018.05.30 BOEHRINGER INGELHEIM MICROPARTS GMBH
  • EP2611594B1 patent drawingFigure 1
  • EP2611594B1 patent drawingFigure 2
  • EP2611594B1 patent drawingFigure 3

AI summary

The invention proposes a process and a laminating device for producing a microfluidic apparatus, wherein a film is pressed onto a backing under the action of heat and is thereby bonded to the latter. During the bonding process, the film is raised by the injection of gas on the backing side such that it cannot adhere in a non-bonding region, and is vented on the side remote from the backing. The apparatus is pressed together between a holder and a thermode of the laminating device during the lamination. A respective elastic intermediate layer is arranged between the apparatus and the holder and also between the apparatus and the thermode to make the contact pressing force more uniform and to make the bonding between the film and the backing more uniform.