Microfluidic Detection Layout With Organic Transistors for Small Samples
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Solution Overview
Problem
Existing micro-fluidic reaction devices face limitations in detection sensitivity, require costly equipment, and involve complex operations, making accurate quantitative detection of biomolecules challenging, especially for small sample volumes.
Innovation Solution
A micro-fluidic detection device integrating inorganic and organic transistors within a dual-layer structure, allowing for simultaneous droplet manipulation and detection, with separate units for reaction and detection, utilizing hydrophilicity and hydrophobicity differences for sample transfer, and employing organic transistors for enhanced sensitivity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If existing micro-fluidic reaction devices are used for detection, then droplet manipulation functions are achieved, but detection sensitivity is insufficient and accurate quantitative detection of biomolecules is difficult
Solution Approach 1:
The patent combines the micro-fluidic reaction device with an organic transistor detector to form an integrated detection system. The organic transistor is positioned directly above the reaction chamber, allowing the detection electrode to contact the reaction solution directly. This integration merges the droplet manipulation capability of the micro-fluidic device with the high sensitivity of the organic transistor detector, resolving the contradiction between detection sensitivity and device complexity.
Solution Approach 2:
The patent introduces an organic transistor as an intermediary detection element between the micro-fluidic reaction chamber and the measurement system. The organic transistor's detection electrode acts as a mediator that directly contacts the reaction solution and converts biochemical signals into electrical signals, enabling accurate quantitative detection while maintaining the simplicity of the micro-fluidic device structure.
2Measurement precision
If costly equipment and complicated operations are used, then detection accuracy may be improved, but sample demand increases and costs rise
Solution Approach 1:
The organic transistor detector enables the system to perform self-detection without requiring complex external equipment. The detection electrode directly contacts the reaction solution in the micro-fluidic chamber, allowing the device to detect biomolecules autonomously. This self-service capability reduces sample demand and eliminates the need for costly external detection equipment while maintaining quantitative detection accuracy.
3Productivity
If separate reaction and detection processes are used, then each process can be optimized, but detection time increases and efficiency decreases
Solution Approach 1:
The patent merges the reaction and detection processes into a single integrated device. The organic transistor detector is positioned directly above the reaction chamber, allowing detection to occur simultaneously with or immediately after the reaction without requiring separate equipment or additional sample transfer steps. This integration significantly reduces detection time and improves efficiency while maintaining process optimization.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device achieves fixed-point, timed, and quantitative biological reactions with reduced sample demand, lower costs, and improved detection efficiency and accuracy by integrating reaction and detection functions, while minimizing space and process complexity.
Implementation Method 1
The detection unit circuit at least includes an inorganic transistor and an organic transistor. The organic transistor at least includes an organic semiconductor part and is electrically connected to a sensitive electrode.
Implementation Method 2
The first hydrophobic layer is located on the side of the drive array layer facing the second base plate. The second hydrophobic layer is located on a side of the second electrode layer facing the first base plate.
Data Source
AI summary
A micro-fluidic detection device includes a first base plate, a second base plate opposite to the first base plate, and a droplet travel layer located between the first and second base plates. The first base plate includes a first substrate, a drive array layer, a first electrode layer, and a first hydrophobic layer. The second base plate includes a second substrate, a second electrode layer, and a second hydrophobic layer. Drive electrodes of the first electrode layer are at first units. The first unit includes a micro-fluidic unit circuit. A second unit includes a detection unit circuit. The detection unit circuit includes inorganic transistors and organic transistors. A sensitive electrode is at the second unit. The sensitive electrode is on a side of a layer where the inorganic transistor is located away from the first substrate. A first hollow hole of the first base plate exposes the sensitive electrode.