Microfluidic Device Bonding via Sealing Lip Injection Molding

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Solution Overview

Problem

Conventional bonding techniques for microfluidic devices often cause distortion and deformation due to high temperatures and pressures, leading to poor alignment and bond quality, especially when using polymer materials like cyclic olefin polymer and polystyrene.

Innovation Solution

The method involves selecting the geometry and dimensions of the base and cap components to facilitate injection molding, using a sealing lip on the cap component to prevent deformation and improve bonding by injecting a polymer material between the components, which adheres them without applying excessive pressure or heat.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If conventional bonding techniques are used to bond base and cap components, then the microfluidic device can be assembled, but the materials may burn or melt causing dimension distortion

Engineering Contradiction:
Improvebonding capabilityVSAvoiddimensional accuracy
Core Design Contradiction:
Ease of manufactureVSManufacturing precision

Solution Approach 1:

The patent introduces a bonding layer as an intermediary substance between the base and cap components. This bonding layer enables the bonding process to proceed without directly heating or pressurizing the microfluidic device components to damaging levels, thus preventing burning or melting while still achieving reliable assembly. The bonding layer acts as a buffer that facilitates adhesion without transmitting excessive thermal and mechanical stress to the delicate microfluidic structures.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Strength

If high temperature and pressure are applied during bonding, then the components can be adhered together, but the microfluidic device dimensions become distorted

Engineering Contradiction:
Improvebond strengthVSAvoiddimensional accuracy
Core Design Contradiction:
StrengthVSManufacturing precision

Solution Approach 1:

The patent modifies the bonding parameters by introducing a bonding layer that changes the thermal and mechanical properties of the bonding interface. This allows bonding to occur at reduced temperatures and pressures compared to direct bonding methods. The bonding layer's specific material properties enable adhesion at lower energy inputs, thereby preventing dimension distortion while maintaining adequate bond strength for device functionality.

Inventive Principle:
Principle #35Parameter changes

3Manufacturing precision

If geometry and dimensions are optimized for injection molding, then deformation is reduced, but the device complexity increases

Engineering Contradiction:
Improvedimensional stabilityVSAvoidgeometry complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent divides the microfluidic device into separate base and cap components that can be independently manufactured using injection molding. This segmentation allows each component to be optimized for molding processes while maintaining dimensional stability. The bonding layer connects these segmented components, enabling the overall device to achieve both manufacturing precision through optimized individual part geometry and functional complexity through modular assembly.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach reduces the risk of material deformation and enhances bond quality, ensuring the microfluidic device maintains its dimensions and performance by avoiding the adverse effects of conventional bonding methods.

Implementation Method 1

The injected polymer material can cause the base component to become adhered to the cap component

Methodology Applied
Scientific EffectAdhesion: Adhesive

Data Source

PatentEP4034492B1Systems and methods for manufacturing closed microfluidic devices
Publication Date: 2023.12.27 THE CHARLES STARK DRAPER LABORATORY INC
  • EP4034492B1 patent drawingFigure 1
  • EP4034492B1 patent drawingFigure 2
  • EP4034492B1 patent drawingFigure 3

AI summary

A method for manufacturing a microfluidic device can include providing a base component to define a first portion of the microfluidic device. A cap component of the microfluidic device can be fabricated with a sealing lip extending a first distance from a first side of the cap component and a support portion extending a second distance, less than the first distance, from the first side of the cap component. The method can include positioning the cap component and the base component within a mold to bring the sealing lip of the cap component in contact with the base component. The base component, the support portion of the cap component, and the sealing lip of the cap component together can define a cavity. The method can include injecting a polymer material into the mold to cause the polymer material to fill the cavity.