Micrometer Syringe for Precise Cellular Material Delivery
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Solution Overview
Problem
Current methods for injecting small amounts of material, such as cells, are problematic due to damage caused to the cells during aspiration and the need for two-handed operation of micrometer/syringe systems, which can lead to unwieldy designs and material loss upon needle removal.
Innovation Solution
A micrometer assisted fluid delivery device with a syringe arrangement that allows for precise control of cellular material injection, featuring a syringe with finger tabs and a micrometer with a spindle that can be rotated to inject material at an angle, minimizing cell damage and preventing material loss by twisting the needle before removal.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If a micrometer head is used with a syringe to deliver precise small amounts of fluid, then manufacturing precision is improved, but device complexity increases and ease of operation deteriorates due to requiring two hands
Solution Approach 1:
The micrometer head is integrated directly into the syringe plunger mechanism, merging two separate components (micrometer head and syringe) into a single unified device. This integration allows the micrometer to be operated with one hand while the syringe body is held steady, eliminating the need for two-handed operation and reducing overall device complexity
Solution Approach 2:
The integrated micrometer-syringe device performs multiple functions: precise volume control through the micrometer mechanism, fluid delivery through the syringe, and aspiration capability through the same integrated system. This multi-functionality eliminates the need for separate micrometer and syringe operations, improving ease of operation while maintaining precision
2Quantity of substance
If cells are aspirated into a syringe for injection, then quantity of substance is improved, but object-affected harmful factors worsen due to damage to cell morphology
Solution Approach 1:
The device allows for preliminary aspiration of cellular material into the syringe before injection, enabling the operator to prepare the exact amount needed for injection in advance. This preliminary action allows for gentle handling and positioning of cells in the syringe, reducing mechanical damage to morphology while ensuring the correct quantity is ready for delivery
Solution Approach 2:
The micrometer mechanism replaces traditional mechanical syringe operation, providing precise control over the injection process through incremental rotation rather than forceful plunger depression. This substitution reduces mechanical stress on cells during both aspiration and injection, preserving cell morphology while maintaining accurate delivery of the required quantity
3Loss of substance
If the needle is removed from the injection site after injecting small amounts of material, then loss of substance worsens due to material being pulled back
Solution Approach 1:
The micrometer mechanism allows for preliminary positioning and controlled deployment of the needle at the exact angle and depth required, ensuring optimal placement before material injection begins. This preliminary action ensures that when the needle is removed, the material remains firmly deposited at the injection site, preventing pull-back loss while maintaining efficient delivery
Data Source
AI summary
The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.