Dissolvable Microneedle Composition for Fast Release and Manufacturability
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Solution Overview
Problem
Dissolvable microneedles face issues of slow dissolution rate and manufacturing difficulties due to material properties and processing challenges.
Innovation Solution
A microneedle device composed of polyglutamic acid and pullulan, with a weight ratio ranging from 0.1 to 0.9, ensures rapid dissolution and manufacturing feasibility by optimizing the material composition and viscosity for effective microneedle formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If dissolvable microneedles are made from materials such as carbohydrates and polymers, then rapid release of macromolecules is promoted, but dissolution rate is slow and manufacturing is difficult
Solution Approach 1:
The patent uses a composite material system consisting of polyglutamic acid and pullulan. Polyglutamic acid provides rapid dissolution and macromolecule release, while pullulan provides structural integrity and manufacturing feasibility. This composite approach resolves the contradiction by combining the advantages of both materials to achieve both fast dissolution and ease of manufacture.
Solution Approach 2:
The patent optimizes the weight ratio of polyglutamic acid to pullulan within the range of 0.1 to 0.9, and controls the molecular weight of polyglutamic acid between 400-1000 kDa and pullulan between 200-1000 kDa. By adjusting these parameters, the patent achieves the optimal balance between dissolution rate and manufacturing feasibility.
2Productivity
If polyglutamic acid content is increased to improve dissolution rate, then dissolution speed increases, but manufacturing feasibility decreases
Solution Approach 1:
The patent establishes an optimal weight ratio range of polyglutamic acid to pullulan (0.1 to 0.9) and controls molecular weights within specific ranges. This parameter optimization ensures that polyglutamic acid provides sufficient dissolution performance while maintaining manufacturability through appropriate material proportions.
Solution Approach 2:
The composite material system balances the dissolution-promoting effect of polyglutamic acid with the manufacturing-friendly properties of pullulan. The synergistic combination allows achieving fast dissolution without compromising manufacturing feasibility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device achieves fast dissolution rates, with microneedles dissolving more than 50% in 1 hour and 70% in 2 hours, and maintains structural integrity during manufacturing.
Implementation Method 1
The microneedle device provided by the present invention includes a base and a plurality of microneedles. The plurality of microneedles is arranged on the surface of the base, wherein the material of the base and the plurality of microneedles include polyglutamic acid and pullulan
Implementation Method 2
the tens of thousands of microneedles (MN) allow macromolecules and drugs to penetrate the stratum corneum and enter the skin through micro-pores
Data Source
AI summary
A microneedle device including a base and a plurality of microneedles is provided. The microneedles are arranged on a surface of the base, wherein the material of the base and the microneedles include polyglutamic acid and pullulan. The ratio of the weight of polyglutamic acid to the weight of pullulan is ranged from 0.1 to 0.9. The microneedle device dissolves quickly and is easy to prepare.