Microneedle Particle Composition for Partial Tissue Penetration
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Solution Overview
Problem
Existing methods for delivering bioactive compounds through biological tissues, such as skin, are limited by the strong barrier functionality of these tissues, leading to ineffective delivery and potential tissue damage due to long scratches or the need for multiple needle structures that are difficult to administer and limited in surface area coverage.
Innovation Solution
Microneedle particles with a core structure and extending microneedles are designed to partially penetrate biological tissues, forming microchannels while preventing the entire particle from embedding, allowing for flexible application and removal, and can be dispersed in a liquid medium with bioactive agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If abrasive methods are used to penetrate biological tissue, then penetration is achieved, but tissue damage increases due to removal of large areas of tissue
Solution Approach 1:
The invention divides the tissue penetration function into multiple discrete microneedle elements (e.g., 10-1000 microneedles per particle) rather than using a single abrasive surface. Each microneedle creates an individual microchannel, segmenting the penetration process to minimize tissue removal while achieving sufficient depth through the stratum corneum.
Solution Approach 2:
The invention transitions from two-dimensional abrasive scratching (parallel to tissue surface) to three-dimensional puncture penetration (perpendicular to tissue surface). The microneedles are configured to penetrate vertically through the tissue barrier, creating discrete channels that minimize lateral tissue removal while achieving effective delivery depth.
2Object-affected harmful factors
If multiple needle structures are used to puncture tissue, then discrete punctures are created, but device complexity and difficulty of administration increase
Solution Approach 1:
The invention merges multiple individual needle structures into a single integrated microneedle particle. The particle comprises a core structure with multiple microneedles extending from it, combining the functions of many separate needles into one applyable unit that can be administered as a single composition rather than requiring assembly of multiple components.
Solution Approach 2:
The invention introduces a liquid or gel composition as an intermediary medium that carries the microneedle particles to the tissue surface. This mediator facilitates easy application and distribution of the microneedles across the treatment area, eliminating the need for complex mechanical assembly or specialized administration devices.
3Area of stationary object
If microneedle patches are used for skin pretreatment, then tissue penetration is achieved, but treatment surface area is limited by patch size
Solution Approach 1:
The invention changes the physical state and delivery parameters of the microneedles by incorporating them into a liquid or gel composition. This allows the microneedle particles to be applied flexibly across large surface areas using conventional topical application methods, rather than being constrained by the fixed size and shape of solid patches.
4Productivity
If ballistic methods are used to puncture tissue, then penetration is achieved, but particles become completely embedded in tissue requiring removal
Solution Approach 1:
The invention applies partial penetration action where the microneedles are designed to penetrate only to the required depth (through the stratum corneum) rather than completely through the tissue. The core structure prevents excessive penetration, allowing the microneedles to create effective channels while remaining partially external for easy removal, avoiding the need for surgical extraction.
Data Source
Figure 1A~2B
Figure 3A~3C
Figure 4A~4B
AI summary
Provided herein is a composition comprising a plurality of microneedle particles (100) and a liquid medium in which the plurality of microneedle particles (100) is dispersed. The composition is adapted for application to a biological tissue surface. Each of the microneedle particles (100) comprises a core structure (110) and one or more microneedles (120) extending from the core structure. The microneedles (120) are structured to penetrate the biological tissue surface. At least one of the core structure (110),the one or more microneedles (120), and a spatial relationship between/among two or more of the microneedles (120) is configured to prevent the entire microneedle particle (100) from penetrating the biological tissue surface.