Microneedle Indentation Management via Conductivity Feedback

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Solution Overview

Problem

Existing body monitoring devices using microneedles face difficulties in maintaining stable insertion into the skin for continuous or quasi-continuous biochemical parameter monitoring, particularly for pathologies like diabetes, where invasive methods are less preferred.

Innovation Solution

A body monitoring system with analyte measuring microneedles configured to sample and analyze bodily fluids, featuring conductivity electrodes to measure insertion depth, ensuring proper placement and functionality, integrated with a housing and processor for data processing and management.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If microneedles are used for transcutaneous monitoring, then invasiveness is reduced, but microneedle retention and stable insertion into skin is difficult to maintain

Engineering Contradiction:
ImproveinvasivenessVSAvoidmicroneedle retention
Core Design Contradiction:
Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent implements a feedback mechanism where conductivity electrodes continuously measure the electrical conductivity between the microneedle and reference electrode, providing real-time information about insertion depth and skin contact quality. This feedback allows the system to monitor and maintain reliable microneedle retention, resolving the contradiction between reduced invasiveness and reliable retention.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent replaces mechanical retention mechanisms (such as adhesive strips or physical anchoring) with an electrical field-based retention system. Conductivity electrodes create an electrical field that detects and maintains microneedle insertion through conductivity measurements, eliminating the need for complex mechanical retention structures and reducing overall invasiveness while maintaining reliability.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Measurement precision

If conductivity electrodes are added to measure insertion depth, then microneedle placement accuracy is improved, but device complexity increases

Engineering Contradiction:
Improveinsertion depth measurementVSAvoiddevice structure
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The conductivity electrodes serve multiple functions: they measure insertion depth, monitor skin contact quality, and provide feedback on microneedle retention status. This multi-functionality allows the system to achieve precise insertion depth measurement without adding separate dedicated components for each function, thereby limiting the increase in device complexity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent merges the conductivity measurement function with the existing microneedle structure by integrating conductivity electrodes directly onto the microneedle array substrate. This integration combines multiple functions into a single unified structure, achieving precise measurement capabilities while minimizing the increase in overall device complexity.

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables continuous, less invasive monitoring of biochemical parameters by ensuring accurate microneedle insertion and operation, enhancing the reliability and effectiveness of body fluid analysis without frequent skin piercing.

Implementation Method 1

a conductivity measuring electrode configured to measure the depth of penetration into the epidermis of the analyte measuring microneedle

Methodology Applied
Scientific EffectElectrical conductivity: Conduction (electrical)

Implementation Method 2

the analyte measuring microneedles each comprising on their surface a biochemical material capable of reacting with the analyte

Methodology Applied
Scientific EffectBiochemical reaction:

Data Source

PatentEP3829437B1Microneedle indentation management
Publication Date: 2024.11.06 WIZP AS
  • EP3829437B1 patent drawingFigure 1
  • EP3829437B1 patent drawingFigure 2~3
  • EP3829437B1 patent drawingFigure 4~6

AI summary

The invention relates to a sensor (220) for a body monitoring system (1), comprising analyte-measuring microneedles (210) that extend parallel to a main direction (Z) from a substrate (242) and define a working plane (Pt), characterized in that the sensor (220) comprises at least one conductivity electrode (600) with a metallic track (602), the end of the metallic track extending along the main direction (Z) to a position strictly between the substrate (242) and the working plane (Pt).