Micronized Amnion-Chorion Composition Preserving Wound Healing Factors
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Solution Overview
Problem
Existing human placental tissue compositions for wound healing lose endogenous growth factors due to extensive processing, leading to reduced wound healing capabilities.
Innovation Solution
Micronized compositions comprising intact human amnion, chorion, and intermediate spongy layer, minimally processed to preserve growth factors, avoiding harsh methods like cryofracturing and lyophilization.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If extensive processing is applied to human placental tissue compositions, then the tissue can be prepared for wound healing applications, but endogenous growth factors are lost leading to reduced wound healing capabilities
Solution Approach 1:
The patent changes the processing parameters from harsh methods (cryofracturing, lyophilization) to gentle methods that preserve growth factors. Specifically, it uses minimal processing, avoids freezing and drying steps, and maintains physiological conditions throughout preparation, thereby preserving the endogenous growth factor profile while still preparing the tissue for wound healing applications
Solution Approach 2:
The patent extracts only the necessary components for wound healing (the intact amnion-chorion structure with intermediate spongy layer) without removing the growth factors. Instead of extracting growth factors separately or using processing that removes them, the invention maintains the complete native structure with all endogenous factors intact
2Reliability
If harsh processing methods like cryofracturing and lyophilization are used, then the tissue can be prepared and stabilized, but endogenous growth factors are degraded
Solution Approach 1:
The patent converts the potential harm of processing into benefit by using minimal processing that actually protects growth factors. Instead of using harsh methods that stabilize tissue through degradation, the invention uses gentle handling and storage conditions that maintain both tissue integrity and growth factor activity, turning the challenge of stabilization into an opportunity to preserve native functionality
3Ease of manufacture
If the amnion and chorion are physically separated and processed individually, then the composition can be manufactured, but portions of the intermediate spongy layer are lost and growth factor profiles are altered
Solution Approach 1:
The patent merges the amnion, intermediate spongy layer, and chorion into a single intact composite structure for manufacturing. Instead of separating these layers and processing them individually, the invention maintains their natural association throughout the manufacturing process, ensuring that the complete growth factor profile including factors from the intermediate spongy layer is preserved
Data Source
AI summary
A sterile micronized composition prepared from intact human placental tissue that is configured for wound healing. The sterile micronized composition includes micronized human amnion; micronized human chorion; and micronized human intermediate spongy layer. In certain aspects, the composition is prepared from intact placental tissue comprising a human amnion layer, human chorion layer, and an intact human intermediate spongy layer positioned between the human amnion layer and human chorion layer such that immediately before micronization the human amnion layer and the human chorion layer are not separated from one another.