Micronized Cartilage Powder Composition for Regeneration
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Solution Overview
Problem
Current cartilage regeneration methods face limitations such as incomplete regeneration, high cost, immune response risks, and procedural complexities, particularly with existing human-derived cartilage products like DeNovo-NT and BioCartilage, which have short shelf life and require manual mixing with PRP for application.
Innovation Solution
A method involving the preparation of micronized cartilage powder through lyophilization, crushing, and sieve-separation, combined with delipidation and decellularization, and mixing with a biocompatible polymer or its crosslinked product to create a composition that can be physically aggregated for transplantation, enhancing cartilage regeneration and reducing immune responses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If human-derived cartilage is processed into particles and granules for direct application, then cartilage regeneration is improved, but the shelf life becomes very short and distribution is limited
Solution Approach 1:
The patent changes the physical state of cartilage from fresh tissue to freeze-dried powder form, fundamentally altering its storage stability and shelf life while maintaining regenerative capability when rehydrated at the application site
Solution Approach 2:
The cartilage is pre-processed into a stable powder form before storage, with all necessary preparation done in advance. This preliminary processing allows the product to be stored indefinitely and only requires simple rehydration before use, eliminating the need for complex cold chain distribution
2Ease of operation
If cartilage particles are simply provided in sterile physiological saline, then ease of use is maintained, but morphological retention at the injury site is poor
Solution Approach 1:
The patent introduces a hydrogel carrier as an intermediary substance that holds the cartilage powder particles. This hydrogel matrix provides structural support and morphological retention at the injury site while still allowing the cartilage particles to function, combining the ease of injection with improved shape retention
3Reliability
If DeNovo-NT is used with particles of 500 to 1000 μm, then cartilage regeneration is achieved, but the product requires post-mortem donor cartilage and has limited acquisition
Solution Approach 1:
The patent changes the particle size parameter to a finer micronized powder form and transforms the material state to freeze-dried powder, which can be derived from various cartilage sources including waste cartilage, thereby expanding the availability and adaptability of the product
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively induces homogenous cartilage regeneration with improved morphological retention and ease of use, overcoming previous limitations by minimizing immune responses and providing effective cartilage repair compared to microfracture alone.
Implementation Method 1
a method involving the preparation of micronized cartilage powder through lyophilization, crushing, and sieve-separation
Data Source
AI summary
A composition includes a cartilage component for regeneration of cartilage and a manufacturing method therefor. A composition for regeneration of cartilage, in which a micronized cartilage powder is physically mixed with a biocompatible polymer or a chemically crosslinked biocompatible polymer. When applied, the composition can increase morphological retention and ease of use at cartilage injury sites.