Microparticle Forming Device Uniform Particle Size
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Solution Overview
Problem
Conventional microparticle forming devices produce microparticles with inconsistent particle sizes and poor roundness, affecting their drug-releasing consistency.
Innovation Solution
A microparticle forming device comprising a collection pipe with aqueous-phase and oil-phase fluid inlets, a reactor with a mixing member, and a filter, utilizing a fluid nozzle that induces directional droplet spray and a tangential flow filtrator to achieve uniform particle size and roundness, while removing organic solvents to maintain emulsification reaction efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional electrostatic field microparticle forming device is used, then microparticles can be formed, but particle size uniformity and roundness are poor
Solution Approach 1:
The device segments the microparticle formation process into distinct stages: droplet generation in the collection pipe, emulsification in the reaction chamber, and filtration through the tangential flow filter. This segmentation allows each stage to be optimized independently, improving overall particle uniformity and roundness
Solution Approach 2:
The patent introduces an intermediary organic solvent system that facilitates controlled emulsification. The solvent acts as a mediator between the aqueous phase and polymer solution, enabling uniform microparticle formation while maintaining proper roundness through controlled phase separation
2Productivity
If organic solvent is present in the system, then emulsification reaction can proceed, but organic solvent interference reduces reaction effectiveness
Solution Approach 1:
The tangential flow filter is positioned to remove organic solvent from the aqueous phase before the emulsification reaction reaches its critical stage. This preliminary removal action prevents solvent interference while maintaining reaction efficiency
Solution Approach 2:
The device extracts and removes the harmful organic solvent component from the reaction system using the tangential flow filtration system. This extraction eliminates the harmful effect of solvent interference while preserving the beneficial emulsification process
3Productivity
If fluid flow rate is increased to improve productivity, then more microparticles can be produced, but particle size uniformity deteriorates
Solution Approach 1:
The device employs dynamic control of fluid flow rates through independently adjustable pumps for each inlet. This allows the system to adapt flow conditions to maintain optimal particle uniformity while maximizing production rate through coordinated multi-phase flow control
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively produces microparticles with uniform particle size and proper roundness, ensuring consistent drug release and maintaining emulsification reaction effectiveness by removing organic solvent interference.
Implementation Method 1
the fluid nozzle uses the standing wave effect to induce the directional micro droplets spray
Implementation Method 2
Fluid can be ejected in the form of a liquid jet through the operation of the piezoelectric nozzle 91
Implementation Method 3
When the liquid jet passes between the two electric field generating members 92, 93, it is broken into a plurality of droplets under the pulling of the electrostatic force
Data Source
AI summary
A microparticle forming device is used to form microparticles with uniform particle size and proper roundness, and includes a collection pipe, a fluid nozzle, a reactor and a filter. The collection pipe includes a fluid passage, an aqueous-phase fluid inlet, an oil-phase fluid inlet and a mixed fluid outlet, all of which communicate with the fluid passage. The oil-phase fluid inlet is located between the aqueous-phase fluid inlet and the mixed fluid outlet. The fluid nozzle has a plurality of oil-phase fluid drop outlets aligned with the oil-phase fluid inlet of the collection pipe. The reactor has a reaction chamber communicating with the mixed fluid outlet of the collection pipe, a mixing member accommodated in the reaction chamber, and a microparticle collection port communicating communicated with the reaction chamber. Two opposite ends of the filter respectively communicate with the reaction chamber of the reactor.