Microparticle Composition for Selective GI Tract Delivery
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current products aimed at mitigating the effects of excessive alcohol consumption are ineffective in addressing cognitive and motor impairment, as they often require pre-consumption, have limited efficacy, and fail to provide timely relief, leading to continued risk-taking behaviors and accidents.
Innovation Solution
A composition-of-matter comprising three types of microparticles with different release profiles in the GI tract, containing dietary supplements that affect motor and cognitive performance, anti-gastroparesis, antiemetic, analgesic, and anti-inflammatory activities, and alcohol catabolism, designed to be consumed post-alcohol consumption to accelerate metabolism and alleviate symptoms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If powder-based products are used to mitigate alcohol effects, then active ingredients can be delivered, but the products require pre-consumption timing and have limited efficacy for cognitive and motor impairment
Solution Approach 1:
The product is segmented into three distinct microparticle types, each with different release profiles (rapid release in stomach, delayed release in intestine, delayed release in colon). This segmentation allows different active ingredients to be delivered to different GI tract locations at different times, ensuring continuous relief from alcohol effects without requiring pre-consumption timing.
Solution Approach 2:
The microparticles are pre-formulated with specific coating materials designed to dissolve at different pH levels and locations in the GI tract. This preliminary action ensures that active ingredients are released at the optimal time and location, providing immediate relief for stomach-related symptoms and sustained relief for cognitive and motor impairment throughout the intestine and colon.
2Duration of action of moving object
If single-release-profile microparticles are used, then manufacturing is simpler, but the product cannot provide sustained relief across different GI tract regions
Solution Approach 1:
The formulation is divided into three microparticle types with distinct release profiles, allowing each particle type to target a specific GI tract region. This segmentation enables sustained relief throughout the entire digestive process while maintaining relatively simple manufacturing for each individual particle type.
Solution Approach 2:
Each microparticle type serves multiple functions: protecting active ingredients from degradation, controlling release timing, and targeting specific GI tract regions. This multi-functionality reduces the need for separate delivery systems for each function, balancing complexity with comprehensive performance.
3Productivity
If active ingredients are released rapidly in the stomach, then immediate relief from nausea and gastroparesis is achieved, but cognitive and motor impairment persists
Solution Approach 1:
The delivery system segments active ingredient release into three temporal and spatial phases: rapid release in the stomach for immediate symptom relief, delayed release in the intestine for cognitive and motor function recovery, and delayed release in the colon for sustained effect. This segmentation ensures both rapid productivity and reliable long-term recovery.
Solution Approach 2:
Different microparticle types are distributed to different GI tract locations with tailored release properties. The rapid-release particles target the stomach for immediate anti-gastroparesis effects, while delayed-release particles target the intestine and colon for cognitive and motor performance recovery, ensuring local quality matches local needs.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively accelerates alcohol metabolism by up to 100%, reduces cognitive and motor impairment, and alleviates physiological symptoms such as nausea and fatigue, providing relief within 5-10 minutes and lasting up to 8 hours, while being taste-neutral and effective across a range of blood alcohol levels.
Implementation Method 1
a microparticle facilitating rapid release of said active ingredient in the stomach, a microparticle facilitating delayed release of said active ingredient in the intestine, and a microparticle facilitating delayed release of said active ingredient in the colon
Data Source
Figure 1~2
Figure 3
Figure 4
AI summary
A composition-of-matter is provided. The present composition includes dietary supplements capable of reducing or reversing the negative effects of alcohol on motor and cognition, dietary supplements having anti-gastroparesis, antiemetic, analgesic and anti-inflammatory activities and/or dietary supplements capable of increasing alcohol catabolism and decreasing the level of toxic products of alcohol catabolism.