Microparticle Sorting Control Device for Cell Survival Optimization
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Solution Overview
Problem
Current microparticle sorting technologies face challenges in efficiently and effectively sorting microparticles, particularly in determining the optimal processing conditions for cell preparation, such as accurately defining the number of effective cells and impurities, and achieving sufficient cell survival and activation rates, often requiring excessive cell production and long processing times.
Innovation Solution
A control device and system that adjusts sorting processing conditions based on pre-measurement data, including flow rate, processing time, and interval, to optimize the sorting of bio-related microparticles by controlling the sorting unit using a control unit that calculates and sets conditions based on the content, surviving rate, and activation rate of microparticles in the sample liquid.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional microparticle sorting is used to produce cell preparation, then cell sorting can be performed, but it is difficult to define the amount of effective ingredient and impurities, and excessive cell production is required
Solution Approach 1:
The system performs pre-measurement of microparticle content in the sample liquid before sorting, uses this measurement data to calculate required sorting conditions, and adjusts the sorting process accordingly. This feedback loop enables precise definition of effective ingredient amounts without excessive cell production.
Solution Approach 2:
The system performs pre-measurement of microparticle content before the sorting process to determine the exact amount of effective ingredients and impurities. This preliminary action allows precise planning of sorting parameters to achieve the desired cell preparation without producing excessive cells.
2Productivity
If sorting processing time is reduced, then productivity increases, but cell surviving rate and activation rate decrease
Solution Approach 1:
The system dynamically adjusts sorting processing conditions including flow rate, processing time, and interval based on pre-measurement data of microparticle content. This dynamic optimization enables shortening processing time while maintaining cell surviving rate and activation rate by precisely matching sorting parameters to the actual sample characteristics.
Solution Approach 2:
The system changes sorting parameters (flow rate, processing time, interval) based on pre-measurement results to optimize both productivity and cell quality. By adjusting these parameters according to actual microparticle content, the system achieves high productivity without compromising cell surviving rate.
3Device complexity
If sorting processing conditions are fixed, then device complexity is reduced, but adaptability to different sample compositions decreases
Solution Approach 1:
The system changes sorting processing conditions (flow rate, processing time, interval) based on pre-measurement data of different sample compositions. This parameter adjustment enables the device to adapt to various microparticle contents and sample types without increasing hardware complexity.
Solution Approach 2:
The control unit provides multi-functionality by automatically adjusting sorting parameters based on pre-measurement data, enabling the same device to handle diverse sample compositions effectively. This universal control approach eliminates the need for multiple specialized sorting modes or complex hardware configurations.
Data Source
AI summary
To provide a technology of efficiently and effectively sorting microparticles to be sorted from a sample solution. The present technology provides a control device being a device that controls a processing condition when sorting microparticles from a sample liquid flowing through a flow path, the control device provided with a control unit that controls a sorting processing condition on the basis of a content of microparticles to be sorted in the sample liquid. In the control device according to the present technology, the control unit may control the sorting processing condition on the basis of a surviving rate and/or an activation rate of biological particles to be sorted with respect to the sorting processing condition.