Microparticle Suspension Mixing by Two-Step Syringe Oscillation
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Solution Overview
Problem
Existing methods for administering microparticle suspensions in aqueous liquid carriers require a lengthy initial mixing phase of at least 90 seconds, which is deemed inefficient and affects the homogeneity of the suspension.
Innovation Solution
A two-step premixing process involving oscillation of the syringe about its longitudinal axis with specific rotational parameters, followed by a combined injection and mixing phase, ensures rapid and homogeneous distribution of microparticles without interrupting the mixing process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of time
If a single continuous mixing phase is used, then the microparticles are re-suspended, but the mixing time is at least 90 seconds which is too long
Solution Approach 1:
The mixing process is divided into two distinct phases: a first mixing phase with initial mixing parameters (first angular velocity and first angle of rotation) followed by a second mixing phase with different mixing parameters (second angular velocity and second angle of rotation). This segmentation allows optimization of each phase for specific mixing objectives, reducing total time while maintaining homogeneity.
Solution Approach 2:
The mixing parameters are made dynamic by changing the angular velocity and angle of rotation between the two mixing phases. The system transitions from static single-parameter mixing to dynamic multi-parameter mixing, adapting the mixing intensity and pattern to achieve better results in less time.
2Manufacturing precision
If the mixing parameters are kept constant, then the process is simple, but the homogeneity and distribution of microparticles is insufficient
Solution Approach 1:
The mixing process is segmented into two phases with different parameters, allowing each phase to target specific homogeneity requirements. The first phase addresses initial re-suspension while the second phase refines distribution, achieving superior homogeneity without excessive complexity.
Solution Approach 2:
The invention changes the mixing parameters (angular velocity and angle of rotation) between phases to optimize homogeneity. By varying these parameters, the system achieves better microparticle distribution while maintaining a relatively simple two-phase structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method significantly reduces the initial mixing time while maintaining or improving the homogeneity of the microparticle suspension, ensuring stable distribution during infusion or injection.
Implementation Method 1
the receptacle containing the liquid composition to be mixed is oscillated about a longitudinal axis of the receptacle through a first angle of rotation from a first reference point and at a first angular velocity
Implementation Method 2
the receptacle is oscillated about said longitudinal axis through a second angle of rotation from a second reference point and at a second angular velocity
Data Source
Figure 1
Figure 2
Figure 2.1~2.3
AI summary
It is disclosed a method of mixing a liquid composition, wherein said liquid composition comprises microparticles dispersed in an aqueous liquid carrier and wherein said liquid composition is contained in a receptacle having a longitudinal axis, the method comprising: a first premixing step in which the receptacle is oscillated about said longitudinal axis clockwise and counter-clockwise from a first reference point through a first angle of rotation for a first period of time and at a first angular velocity; a second premixing step in which the receptacle is oscillated about said longitudinal axis clockwise and counter-clockwise from a second reference point through a second angle of rotation for a second period of time and at a second angular velocity; and wherein said first angle of rotation is smaller than said second angle of rotation, and said first period of time is shorter than said second period of time. Also disclosed is a device for mixing a liquid composition.