Microscope Control Arrangement for Fluorophore-Based Operation

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Solution Overview

Problem

Existing microscope systems require users to adjust numerous illumination and detection settings, which can be complex and error-prone, especially for inexperienced users when operating in different microscopy modes like wide-field and confocal.

Innovation Solution

A microscope control arrangement that processes fluorophore information to derive control parameters and renders a graphical user interface with fluorophore control widgets, allowing users to adjust settings in a fluorophore-based operation paradigm, simplifying the process and reducing errors.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If users adjust numerous illumination and detection settings manually, then the microscope can be configured for different microscopy modes, but the operation becomes complex and error-prone

Engineering Contradiction:
Improvemicroscopy mode configurationVSAvoidsetting adjustment complexity
Core Design Contradiction:
Adaptability or versatilityVSEase of operation

Solution Approach 1:

The system automatically determines appropriate illumination and detection settings based on the detected fluorophores, eliminating the need for manual configuration. The control arrangement processes fluorophore information and autonomously derives control parameters, allowing the microscope to self-configure for different microscopy modes without user intervention in the complex setting adjustment process

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

A graphical user interface with fluorophore control widgets serves as an intermediary between the user and the complex microscope settings. The interface displays fluorophore information and provides simplified control mechanisms, translating high-level user intentions into appropriate illumination and detection parameters without exposing users to the underlying complexity

Inventive Principle:
Principle #24Intermediary (Mediator)

2Adaptability or versatility

If multiple illumination and detection settings are provided, then the microscope can operate in various modes, but the number of parameters to adjust increases

Engineering Contradiction:
Improvemicroscopy mode supportVSAvoidnumber of control parameters
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The control parameters are segmented and organized by fluorophore type and microscopy mode through the graphical user interface. Each fluorophore control widget presents relevant settings in a structured manner, grouping related parameters together and making the overall system complexity manageable through systematic organization rather than presenting all parameters at once

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The system creates a simplified virtual representation of the microscope settings through the graphical user interface. The fluorophore control widgets present abstracted versions of the actual illumination and detection parameters, allowing users to interact with simplified models rather than the full complexity of the physical system

Inventive Principle:
Principle #26Copying

Data Source

PatentUS20250035908A1Microscope control arrangement, microscope system, method of controlling a microscope and computer program
Publication Date: 2025.01.30 LEICA MICROSYSTEMS CMS GMBH
  • US20250035908A1 patent drawing
  • US20250035908A1 patent drawing
  • US20250035908A1 patent drawing

AI summary

A microscope control arrangement includes one or more processors and one or more storage devices. The one or more processors are configured to process fluorophore information indicating one or more fluorophores, derive control parameters based on the fluorophore information, and render a graphical user interface on a display device. The graphical user interface includes one or more fluorophore control widgets corresponding to the one or more fluorophores indicated by the fluorophore information. Each respective fluorophore control widget includes a first widget zone providing a user feedback indicating the corresponding fluorophore and a second widget zone indicating an illumination intensity associated with the corresponding fluorophore.