Multi-Mode Analytical Microscope Shared Objective Lens Design

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Conventional multi-mode analytical microscopes are inefficient and costly due to redundant and incompatible optical components, leading to difficulties in accurate viewing and analysis when switching between modes, particularly in combining visible, ultraviolet, and infrared wavelength ranges.

Innovation Solution

A microscope design that uses a shared light collection path and optical elements, such as a dark field objective lens and concentrator, to facilitate both UV fluorescence and Raman analysis without the need to swap objectives, allowing for simultaneous imaging and analysis with reduced component redundancy and improved alignment.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If conventional multi-mode analytical microscopes are constructed by superimposing features of different microscopes and spectrometers, then multiple viewing/analysis modes are provided, but the instrument becomes expensive and inefficient with redundant and interfering components

Engineering Contradiction:
Improvemulti-mode viewing/analysis capabilityVSAvoidcomponent redundancy and interference
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent applies universality by designing a single optical element (the objective lens) that performs multiple functions across different wavelength ranges. The objective lens is configured to both collect visible light for microscopy and collect UV light for Raman spectroscopy, eliminating the need for separate optical paths and components for each mode. This multi-functional design reduces component redundancy while maintaining versatility in providing both microscopic viewing and spectrometric analysis.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Reliability

If optical elements are designed for specific wavelength ranges (Vis, UV, IR), then optimal performance in each range is achieved, but the elements are incompatible with other wavelength ranges requiring component exchange

Engineering Contradiction:
Improveoptical performance in specific wavelength rangeVSAvoiddifficulty in switching between modes
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The objective lens is designed with universal functionality to operate effectively across multiple wavelength ranges including visible and UV. This eliminates the need to exchange optical elements when switching between microscopy and Raman spectroscopy modes, as the same lens performs both functions reliably without requiring component exchange.

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Adaptability or versatility

If optics are switched between microscopic viewing and spectrometric analysis modes, then different analysis functions are enabled, but alignment accuracy is compromised

Engineering Contradiction:
Improveswitching between viewing/analysis functionsVSAvoidalignment accuracy between modes
Core Design Contradiction:
Adaptability or versatilityVSMeasurement precision

Solution Approach 1:

By using a single objective lens for both visible light microscopy and UV light Raman spectroscopy, the patent eliminates the need to switch optical elements. This ensures that the region of interest remains precisely aligned and focused across both modes, as the same optical path and focal plane are used for both functions, thereby maintaining measurement precision and alignment accuracy.

Inventive Principle:
Principle #6Universality (Multi-functionality)

4Adaptability or versatility

If multiple separate instruments are combined, then comprehensive analysis capability is achieved, but the physical size and cost of the instrument increase

Engineering Contradiction:
Improvecomprehensive analysis capabilityVSAvoidphysical size and cost
Core Design Contradiction:
Adaptability or versatilityVSWeight of stationary object

Solution Approach 1:

The patent merges the optical collection functions for both microscopy and Raman spectroscopy into a single integrated system. The objective lens simultaneously collects visible light for imaging and UV light for Raman analysis, combining what would traditionally require separate instruments into one compact unit. This reduces the physical size and eliminates redundant components while maintaining comprehensive multi-mode analysis capability.

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables efficient and cost-effective multi-mode analysis by eliminating the need for redundant components and improving alignment accuracy, allowing for precise viewing and analysis of the same region of interest without the need to change optics.

Implementation Method 1

a UV light source to provide UV light to be incident on the sample, thereby inducing the emission of UV fluorescence from the sample

Methodology Applied
Scientific EffectFluorescence: Fluorescence

Implementation Method 2

Raman spectrometric analysis (i.e., analysis of laser light scattered by the sample, which can provide information about the composition of the sample)

Methodology Applied
Scientific EffectRaman scattering: Scattering

Data Source

PatentUS7391509B1Devices and methods for multi-mode analytical microscopy, in particular for UV fluorescence and Raman analysis of samples
Publication Date: 2008.06.24 THERMO ELECTRONICS SCI INSTR LLC
  • US7391509B1 patent drawing
  • US7391509B1 patent drawing

AI summary

An analytical microscope provides both UV fluorescence imaging and spectroscopic analysis of a sample with use of the same light collection element (objective lens or other optical element). An incident UV light beam travels to the sample via a dark field illumination path about the periphery of the collection lens, with the collection lens then collecting the emitted light from the sample and forwarding it to an eyepiece and/or camera for viewing. The sample is also illuminated with a laser through the collection lens to generate Raman emissions, which are then collected through the same collection lens and provided to a spectrograph for wavelength identification. Use of the same collection lens for both imaging and spectroscopic analysis better ensures that any imaged regions of interest on the sample are the same as those being spectroscopically analyzed.