Microscope Stage Positioning With Active Vibration Compensation

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Existing positioning devices for microscopes suffer from vibrations during sample movement, leading to image blurring and distortion, especially at high magnifications, necessitating improved vibration compensation.

Innovation Solution

A positioning device with vibration detection sensors and a controller to generate control signals for plate and z-drive units, actively compensating for vibrations by counteracting them or avoiding resonance frequencies, using motors and piezoelectric elements.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If automatic movement of the microscope stage is implemented to facilitate sample positioning, then productivity is improved, but vibrations occur that cause image blurring and distortion

Engineering Contradiction:
Improveautomatic sample positioning speedVSAvoidimage blurring and distortion
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent implements a feedback control system where vibration sensors detect stage vibrations and the controller processes these signals to generate compensatory control signals for the drive unit. This closed-loop feedback mechanism dynamically adjusts the driving parameters to minimize vibrations while maintaining positioning speed, thereby resolving the contradiction between productivity and image quality.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent utilizes vibration sensors to detect mechanical vibrations of the microscope stage and employs active vibration compensation by generating counter-vibrations through controlled drive unit adjustments. This approach directly addresses the vibration-induced image blurring while preserving the benefits of automatic fast positioning.

Inventive Principle:
Principle #18Mechanical vibration

2Measurement precision

If high magnification is used to achieve better image detail, then measurement precision is improved, but vibrations have a more significant negative impact causing blurring and distortion

Engineering Contradiction:
Improveimage detail resolutionVSAvoidvibration-induced blurring and distortion
Core Design Contradiction:
Measurement precisionVSObject-affected harmful factors

Solution Approach 1:

The feedback control system continuously monitors vibrations and dynamically adjusts drive parameters to compensate for their effects. This is particularly important at high magnifications where even minor vibrations significantly impact image quality. The system maintains measurement precision by actively suppressing vibration-induced blurring through real-time control adjustments.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent dynamically changes driving parameters such as acceleration, velocity, and positioning speed based on detected vibration levels and resonance characteristics. By adapting these parameters in real-time, the system optimizes the trade-off between positioning speed and vibration suppression, ensuring high measurement precision without excessive blurring even at high magnifications.

Inventive Principle:
Principle #35Parameter changes

3Object-affected harmful factors

If vibration compensation is added to the positioning device, then image quality is improved, but device complexity increases

Engineering Contradiction:
Improveimage blurring and distortionVSAvoidpositioning device structure
Core Design Contradiction:
Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The patent employs a feedback-based active vibration compensation system that uses sensors and controllers to detect and counteract vibrations. While this adds components, the approach is more effective than passive compensation methods and can be integrated into existing positioning devices, providing superior image quality improvement relative to the complexity added.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The vibration compensation system is designed to work with the existing positioning device components, with the controller serving dual purposes of positioning control and vibration compensation. The drive unit performs both positioning and vibration counteraction functions, reducing the need for completely separate compensation mechanisms and thereby limiting the increase in device complexity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device provides effective vibration compensation, minimizing image blur and distortion by dynamically reacting to vibrations, especially those caused by resonance, resulting in clearer images during sample positioning and image acquisition.

Implementation Method 1

at least one vibration detection sensor configured to detect a vibration of the microscope stage and to generate a sensor signal corresponding to said vibration

Methodology Applied
Scientific EffectVibration detection: Accelerometer

Implementation Method 2

The controller is further configured to process the sensor signal and to generate a control signal for controlling the plate drive unit based on the processed sensor signal

Methodology Applied
Scientific EffectVibration compensation: Feedback

Implementation Method 3

The controller may be configured to cause the plate drive unit to move the microscope stage at a number of different speeds and/or accelerations, to record the sensor signals corresponding to each of the different speeds and/or accelerations, and to determine at which speeds and/or accelerations the microscope stage experiences resonance based on the recorded sensor signals

Methodology Applied
Scientific EffectResonance: Resonance

Data Source

PatentEP4636455A1Positioning device for a microscope, microscope, and method
Publication Date: 2025.10.22 LEICA INSTRUMENTS (SINGAPORE) PTE LTD
  • EP4636455A1 patent drawingFigure 1
  • EP4636455A1 patent drawingFigure 2
  • EP4636455A1 patent drawingFigure 3

AI summary

A positioning device (102) for a microscope (100) comprises a plate drive unit (110) configured to move a microscope stage (106) of the microscope (100). The microscope stage (106) is configured to receive a sample (108). The positioning device (102) also comprises at least one vibration detection sensor (116, 118, 120) configured to detect a vibration of the microscope stage (106) and to generate a sensor signal corresponding to said vibration, and a controller (126) configured to control at least the plate drive unit (110). The controller (126) is further configured to process the sensor signal and to generate a control signal for controlling the plate drive unit (110) based on the processed sensor signal.