Microscopy Training Data via Parameterized Segmentation Refinement

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

The generation of high-quality training data for machine learning models in microscopy systems is labor-intensive and prone to imprecision due to manual user intervention, especially when adapting to new situations or conditions.

Innovation Solution

A microscopy system and method that uses a parameterized model to adjust a pattern to a segmentation mask, generating an updated segmentation mask that is incorporated into the training data, thereby improving the precision of the training data without manual intervention.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If manual user intervention is used to create segmentation masks for training data, then the training data can be generated, but the process is labor-intensive and prone to imprecision

Engineering Contradiction:
Improveprecision of segmentation maskVSAvoidtime for generating training data
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The system uses the trained machine learning model to automatically generate segmentation masks for new images, allowing the model to serve itself by producing training data without external manual intervention. The model iteratively refines its own training data by generating segmentation masks that are then used to retrain and improve the model.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The parameterized model acts as an intermediary between the initial segmentation mask and the final training data. It adjusts geometric parameters of the segmentation mask to better match the actual objects in the image, producing refined segmentation masks that serve as high-quality training data without requiring manual drawing.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Adaptability or versatility

If more training data is added to cover novel measurement situations, then the model's generalizability improves, but the manual effort and time required increases

Engineering Contradiction:
Improvemodel generalizabilityVSAvoidtraining data generation efficiency
Core Design Contradiction:
Adaptability or versatilityVSProductivity

Solution Approach 1:

The system automatically generates training data for novel situations by using the model to create segmentation masks for new images, eliminating the need for manual annotation of each new scenario. This self-service approach enables rapid adaptation to novel measurement situations while maintaining high productivity.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The system performs preliminary action by pre-adjusting the parameterized model based on the initial segmentation mask before finalizing the training data. This preliminary adjustment of geometric parameters ensures that the training data is pre-optimized for the specific measurement situation, improving model generalizability without requiring extensive manual effort.

Inventive Principle:
Principle #10Preliminary action

3Measurement precision

If a parameterized model is used to adjust the segmentation mask, then the precision of training data improves, but the device complexity increases

Engineering Contradiction:
Improveprecision of segmentation maskVSAvoidcomplexity of computing device
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system uses parameter changes by adjusting geometric parameters (such as position, size, shape) of the parameterized model to match the segmentation mask. This approach improves precision by systematically varying parameters to optimize the fit between the model and the actual objects, while keeping the complexity manageable through focused parameter adjustment rather than full manual annotation.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentUS12437027B2Microscopy system and method for generating training data
Publication Date: 2025.10.07 CARL ZEISS MICROSCOPY GMBH
  • US12437027B2 patent drawing
  • US12437027B2 patent drawing
  • US12437027B2 patent drawing

AI summary

A microscopy system for generating training data for a machine learning model comprises a microscope configured to capture an image. The microscopy system further comprises a computing device configured to generate a segmentation mask based on the image, adjust a pattern described by a parameterized model to the segmentation mask, generate an updated segmentation mask using the adjusted pattern, and incorporate the updated segmentation mask or an image derived from the same in the training data.