Multi-Analyte Microsensor Filament Array for Continuous Body Chemistry Monitoring

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Solution Overview

Problem

Conventional biomonitoring devices are limited in their ability to continuously and comprehensively monitor multiple analytes in the body, providing intermittent and detail-limited information, and are often designed for intermittent use, unable to effectively monitor body chemistry beyond a single analyte due to sensor limitations.

Innovation Solution

A new on-body microsensor system comprising an array of filaments with a substrate, conductive layer, insulating layer, sensing layer, and selective coating, configured to penetrate the skin for continuous or semi-continuous monitoring of multiple analytes, integrated with an electronics module for real-time data processing and analysis.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If conventional biomonitoring devices are used, then device simplicity is maintained, but the ability to continuously monitor multiple analytes is limited

Engineering Contradiction:
Improveability to monitor multiple analytesVSAvoidsensor array complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The device is segmented into multiple independent filaments, each equipped with specific sensors for detecting different analytes. This segmentation allows the system to monitor multiple analytes simultaneously while maintaining manageable complexity through modular architecture.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The filament array platform provides universal functionality by supporting multiple types of sensors on different filaments. Each filament can be configured with specific sensors for different analytes, allowing the same base structure to perform multiple monitoring functions.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Loss of information

If intermittent monitoring is implemented, then device complexity is reduced, but information completeness is limited

Engineering Contradiction:
Improvebody chemistry information completenessVSAvoidcontinuous monitoring system complexity
Core Design Contradiction:
Loss of informationVSDevice complexity

Solution Approach 1:

The system enables continuous monitoring by maintaining constant contact between the filament sensors and interstitial fluid through skin penetration. This continuous action ensures uninterrupted data collection for comprehensive body chemistry information without requiring complex intermittent sampling mechanisms.

Inventive Principle:
Principle #20Continuity of useful action

3Ease of manufacture

If single analyte monitoring is used, then manufacturing simplicity is maintained, but comprehensive health monitoring is limited

Engineering Contradiction:
Improvesensor manufacturing easeVSAvoidmulti-analyte monitoring capability
Core Design Contradiction:
Ease of manufactureVSAdaptability or versatility

Solution Approach 1:

The manufacturing process is segmented into standardized steps for creating individual filaments with specific sensors. Each filament can be manufactured using similar processes, and then assembled into arrays, maintaining manufacturing ease while enabling multi-analyte capability through modular composition.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Different filaments are manufactured with locally optimized sensor configurations for specific analytes. This allows each filament to be tailored for its specific detection function while using standardized manufacturing processes, balancing ease of manufacture with specialized multi-analyte capabilities.

Inventive Principle:
Principle #3Local quality

Data Source

PatentUS20240238569A1Method of manufacturing multi-analyte microsensor with microneedles
Publication Date: 2024.07.18 ONE HEALTH BIOSENSING INC
  • US20240238569A1 patent drawing
  • US20240238569A1 patent drawing
  • US20240238569A1 patent drawing

AI summary

A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.