Microtiter Plate Frame and Inner Part for Microscope Observation

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Solution Overview

Problem

In light microscopy, microtiter plates with frames pose a mechanical obstacle due to their design, preventing the examination of samples in outer cavities because of potential collisions with the microscope objective, while omitting the frame would lead to sample plate instability and potential scratching of the optically transparent bottom.

Innovation Solution

A device comprising a microtiter plate with a frame and an inner part, where the inner part is movable relative to the frame, allowing the optically transparent bottom plate to be positioned above or below the supporting surface, thus preventing collisions with the microscope objective and maintaining sample plate stability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If a frame is added to support the microtiter plate, then the structural stability is improved, but the frame becomes a mechanical obstacle that collides with the microscope objective

Engineering Contradiction:
Improvestructural stabilityVSAvoidmechanical obstacle
Core Design Contradiction:
Stability of the object's compositionVSObject-affected harmful factors

Solution Approach 1:

The microtiter plate is divided into two separate components: a frame and an inner part. The inner part containing the cavities and optically transparent bottom can be removed from the frame, allowing the frame to remain for stability while the inner part is positioned for observation without collision with the objective.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The inner part with the optically transparent bottom is extracted from the frame structure. This allows the inner part to be positioned independently above the supporting surface, eliminating the frame's interference with the microscope objective while the frame continues to provide structural support.

Inventive Principle:
Principle #2Taking out (Extraction)

2Stability of the object's composition

If the microtiter plate lies on the optically transparent bottom, then the supporting function is improved, but the bottom plate becomes scratched and observations become difficult

Engineering Contradiction:
Improvesupporting functionVSAvoidscratching of bottom plate
Core Design Contradiction:
Stability of the object's compositionVSObject-affected harmful factors

Solution Approach 1:

The microtiter plate is segmented into a frame and an inner part. The inner part with the optically transparent bottom is held above the supporting surface by the frame structure, preventing direct contact between the bottom plate and the supporting surface, thus avoiding scratches while maintaining support functionality.

Inventive Principle:
Principle #1Segmentation

3Adaptability or versatility

If the inner part is made movable relative to the frame, then the adaptability for microscope observation is improved, but the device complexity increases

Engineering Contradiction:
Improveadaptability for observationVSAvoiddevice complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The microtiter plate is divided into a frame and an inner part that can be separated. The inner part can be removed from the frame and positioned above the supporting surface for microscope observation, providing adaptability without requiring complex mechanical mechanisms - simply a separable design.

Inventive Principle:
Principle #1Segmentation

Data Source

PatentUS12326550B2Device for holding specimens in a microscope
Publication Date: 2025.06.10 LEICA MICROSYSTEMS CMS GMBH
  • US12326550B2 patent drawing
  • US12326550B2 patent drawing
  • US12326550B2 patent drawing

AI summary

A device for receiving samples in a microscope is provided. The device comprises a microtiter plate. The microtiter plate comprises an inner part with cavities for the samples and with an optically transparent bottom plate, which seals the cavities underneath and a frame which defines a supporting surface and is configured to hold the inner part at least in a first position. The bottom plate is arranged above the supporting surface in the first position of the inner part. The inner part is movable relative to the frame along a direction (A) perpendicular to the supporting surface.