Microtome Object Head Positioning via Sensor Feedback

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Solution Overview

Problem

Existing rotary microtomes lack precise and repeatable positioning of the object head, which is essential for serial image recordings and efficient sectioning of samples.

Innovation Solution

A microtome equipped with an electric drive for motorized movement of the object head, a sensor for detecting the target position, and a control device to stop the object head at the desired position, combined with a mechanical drive train and additional sensors for enhanced accuracy, allowing precise and repeatable positioning.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If manual positioning of the object head is used in rotary microtomes, then the device complexity is reduced, but the positioning precision and repeatability deteriorate

Engineering Contradiction:
Improvepositioning precisionVSAvoiddevice complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent replaces manual mechanical positioning with an automated system comprising an electric drive motor, encoder for position feedback, and control unit. The control unit receives position signals from the encoder and controls the electric drive to position the object head precisely at the target position, eliminating manual operation while achieving high positioning precision and repeatability.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent implements a closed-loop feedback system where an encoder continuously monitors the position of the object head and transmits position signals to the control unit. The control unit compares the actual position with the target position and adjusts the electric drive accordingly, ensuring high positioning accuracy and repeatability through real-time feedback control.

Inventive Principle:
Principle #23Feedback

2Productivity

If automated motorized drive systems are added to improve positioning precision, then the productivity increases, but the device complexity increases

Engineering Contradiction:
ImprovethroughputVSAvoiddevice complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The control unit serves multiple functions: it controls the electric drive for positioning, processes encoder signals for feedback, manages the cutting cycle timing, and coordinates overall microtome operation. This multi-functionality consolidates control responsibilities into a single device, increasing productivity through automation while limiting the growth of device complexity through functional integration.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The automated positioning system operates autonomously without requiring manual intervention. The control unit automatically receives position signals from the encoder, calculates the required drive commands, and positions the object head at the target position throughout the cutting cycle, enabling continuous automated operation that increases throughput while maintaining manageable system complexity.

Inventive Principle:
Principle #25Self-service

3Measurement precision

If the object head is moved continuously during cutting, then the productivity increases, but the positioning precision at target position deteriorates

Engineering Contradiction:
Improvepositioning precisionVSAvoidcycle time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent implements periodic stopping of the object head at the target position during the cutting cycle. The control unit controls the electric drive to move the object head to the target position, stop precisely there for imaging or measurement, then resume movement for the next cutting phase. This periodic stopping ensures high positioning precision at the target position while maintaining overall productivity through efficient cycle management.

Inventive Principle:
Principle #19Periodic action

Data Source

PatentEP3625533B1Microtome and method for positioning a microtome object head
Publication Date: 2022.12.28 LEICA BIOSYSTEMS NUSSLOCH GMBH
  • EP3625533B1 patent drawingFigure 1
  • EP3625533B1 patent drawingFigure 2
  • EP3625533B1 patent drawingFigure 3

AI summary

The invention relates to a microtome comprising a cutter and an object head (5) that can be moved relative to the cutter, an electric drive (16) for the motorised movement of the object head (5), a sensor (21) for detecting the presence of the object head (5) at a target position (z1), and a control unit (18) for actuating the electric drive (16) and for processing signals of the sensor (21), wherein the control unit (18) is configured for actuating the electric drive (16) in order to move the object head (5) and to stop the object head (5) in response to a detecting of the presence of the object head (5) in the target position (z1).