Microwave Antenna Lateral Flow Assay Sensor

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Solution Overview

Problem

Lateral flow assays face challenges in accurately determining the presence and concentration of chemical compounds due to the reliance on visual inspection, which can be unreliable, especially for non-expert users, and may lead to incorrect interpretations or discarding of tests.

Innovation Solution

The integration of electric and magnetic probe sensors, as well as RF/microwave sensors, into the test strip or a test fixture to measure changes in dielectric constant or permeability, allowing for quantitative analysis of chemical compound concentration without the need for visual inspection, enabling more reliable and accurate results.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If visual inspection method is used to determine analyte presence, then the device complexity is low and ease of operation is high, but the measurement precision and reliability are poor

Engineering Contradiction:
Improvemeasurement precisionVSAvoiddevice complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent replaces the mechanical/visual inspection system with an electromagnetic sensing system. Electric and magnetic probe sensors detect changes in dielectric constant and permeability of the chemical compound, converting visual interpretation into automated electromagnetic field measurements. This substitution dramatically improves measurement precision while the integration into the test strip keeps device complexity manageable.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces electromagnetic fields as an intermediary between the chemical compound and the detection system. The sensors measure changes in dielectric constant and permeability, which serve as intermediate physical properties that correlate with analyte concentration. This intermediary approach enables precise quantitative analysis without requiring direct visual inspection of the stain line.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If visual inspection is used, then the ease of operation is high, but the reliability of determination is poor leading to incorrect interpretations

Engineering Contradiction:
ImprovereliabilityVSAvoidease of operation
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The patent implements feedback by continuously monitoring the electromagnetic properties (dielectric constant and permeability) as the chemical compound travels to the stain line region. The system provides real-time quantitative data that feeds back to confirm analyte presence and concentration, eliminating the uncertainty and subjectivity of visual inspection. This feedback mechanism dramatically improves reliability while maintaining ease of operation through automated measurement.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent replaces the subjective human visual inspection system with an objective electromagnetic sensing system. The sensors automatically detect and quantify the chemical compound's electromagnetic properties, eliminating human error and subjectivity. This substitution improves reliability significantly while the automated nature of the measurement maintains ease of operation.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Measurement precision

If optical analysis equipment is used to improve measurement precision, then the measurement precision improves, but the device complexity and cost increase significantly

Engineering Contradiction:
Improvemeasurement precisionVSAvoiddevice complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent integrates electric and magnetic probe sensors directly into the disposable test strip structure. These sensors are simple, low-cost electromagnetic elements that are discarded with each test, eliminating the need for expensive, complex optical analysis equipment. The measurement precision is maintained through the sensors' ability to detect dielectric constant and permeability changes, while device complexity and cost are kept low by using simple electromagnetic components rather than complex optical systems.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent substitutes complex optical analysis equipment with simple electromagnetic sensing elements. Instead of using cameras, light sources, and image processing systems, the patent uses electric and magnetic probes that directly measure electromagnetic properties of the chemical compound. This substitution dramatically reduces device complexity and cost while maintaining measurement precision through direct physical measurement of dielectric constant and permeability.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach provides a non-optical, wide dynamic range method for assessing lateral flow assay measurements, enhancing accuracy and reliability, making it suitable for both professional and home use, and enabling quantitative analysis of chemical compound concentrations.

Implementation Method 1

measuring a feed impedance of the microwave antenna using the instrumentation, the feed impedance of the microwave antenna varying with the amount of the chemical compound

Methodology Applied
Scientific EffectDielectric constant measurement: Dielectric Permittivity

Implementation Method 2

measure changes in dielectric constant or permeability

Methodology Applied
Scientific EffectPermeability measurement: Magnetic Field

Implementation Method 3

a liquid sample...is applied to one end of a test strip consisting of absorbent material that draws said sample by capillary action the entire length thereof

Methodology Applied
Scientific EffectCapillary action: Capillary Action

Data Source

PatentUS20230067165A1Electric, Magnetic, and RF Sensor Based Methods to Register and Interpret Lateral Flow Assay Measurements
Publication Date: 2023.03.02 XTRAVA INC
  • US20230067165A1 patent drawing
  • US20230067165A1 patent drawing
  • US20230067165A1 patent drawing

AI summary

A method for reading a lateral flow assay test strip comprises providing a microwave antenna in proximity of a stain line region of the test strip. The method includes causing a chemical compound to travel to the stain line region, an amount of the chemical compound varying in accordance with a quantity of an analyte. The method comprises connecting an instrumentation to the microwave antenna. The method includes measuring a feed impedance of the microwave antenna using the instrumentation, the feed impedance of the microwave antenna varying with the amount of the chemical compound. The method comprises determining the quantity of the analyte based on the feed impedance of the microwave antenna.