Microwave Antenna Lateral Flow Assay Sensor
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Solution Overview
Problem
Lateral flow assays face challenges in accurately determining the presence and concentration of chemical compounds due to the reliance on visual inspection, which can be unreliable, especially for non-expert users, and may lead to incorrect interpretations or discarding of tests.
Innovation Solution
The integration of electric and magnetic probe sensors, as well as RF/microwave sensors, into the test strip or a test fixture to measure changes in dielectric constant or permeability, allowing for quantitative analysis of chemical compound concentration without the need for visual inspection, enabling more reliable and accurate results.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If visual inspection method is used to determine analyte presence, then the device complexity is low and ease of operation is high, but the measurement precision and reliability are poor
Solution Approach 1:
The patent replaces the mechanical/visual inspection system with an electromagnetic sensing system. Electric and magnetic probe sensors detect changes in dielectric constant and permeability of the chemical compound, converting visual interpretation into automated electromagnetic field measurements. This substitution dramatically improves measurement precision while the integration into the test strip keeps device complexity manageable.
Solution Approach 2:
The patent introduces electromagnetic fields as an intermediary between the chemical compound and the detection system. The sensors measure changes in dielectric constant and permeability, which serve as intermediate physical properties that correlate with analyte concentration. This intermediary approach enables precise quantitative analysis without requiring direct visual inspection of the stain line.
2Reliability
If visual inspection is used, then the ease of operation is high, but the reliability of determination is poor leading to incorrect interpretations
Solution Approach 1:
The patent implements feedback by continuously monitoring the electromagnetic properties (dielectric constant and permeability) as the chemical compound travels to the stain line region. The system provides real-time quantitative data that feeds back to confirm analyte presence and concentration, eliminating the uncertainty and subjectivity of visual inspection. This feedback mechanism dramatically improves reliability while maintaining ease of operation through automated measurement.
Solution Approach 2:
The patent replaces the subjective human visual inspection system with an objective electromagnetic sensing system. The sensors automatically detect and quantify the chemical compound's electromagnetic properties, eliminating human error and subjectivity. This substitution improves reliability significantly while the automated nature of the measurement maintains ease of operation.
3Measurement precision
If optical analysis equipment is used to improve measurement precision, then the measurement precision improves, but the device complexity and cost increase significantly
Solution Approach 1:
The patent integrates electric and magnetic probe sensors directly into the disposable test strip structure. These sensors are simple, low-cost electromagnetic elements that are discarded with each test, eliminating the need for expensive, complex optical analysis equipment. The measurement precision is maintained through the sensors' ability to detect dielectric constant and permeability changes, while device complexity and cost are kept low by using simple electromagnetic components rather than complex optical systems.
Solution Approach 2:
The patent substitutes complex optical analysis equipment with simple electromagnetic sensing elements. Instead of using cameras, light sources, and image processing systems, the patent uses electric and magnetic probes that directly measure electromagnetic properties of the chemical compound. This substitution dramatically reduces device complexity and cost while maintaining measurement precision through direct physical measurement of dielectric constant and permeability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach provides a non-optical, wide dynamic range method for assessing lateral flow assay measurements, enhancing accuracy and reliability, making it suitable for both professional and home use, and enabling quantitative analysis of chemical compound concentrations.
Implementation Method 1
measuring a feed impedance of the microwave antenna using the instrumentation, the feed impedance of the microwave antenna varying with the amount of the chemical compound
Implementation Method 2
measure changes in dielectric constant or permeability
Implementation Method 3
a liquid sample...is applied to one end of a test strip consisting of absorbent material that draws said sample by capillary action the entire length thereof
Data Source
AI summary
A method for reading a lateral flow assay test strip comprises providing a microwave antenna in proximity of a stain line region of the test strip. The method includes causing a chemical compound to travel to the stain line region, an amount of the chemical compound varying in accordance with a quantity of an analyte. The method comprises connecting an instrumentation to the microwave antenna. The method includes measuring a feed impedance of the microwave antenna using the instrumentation, the feed impedance of the microwave antenna varying with the amount of the chemical compound. The method comprises determining the quantity of the analyte based on the feed impedance of the microwave antenna.


