Milbemycin-Pyrethroid Mixture for Resistant Mosquito Control

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Solution Overview

Problem

The development of resistance in arthropod populations, particularly mosquitoes, to pyrethroids poses a significant challenge in effective pest control, as current insecticides may become ineffective, and there is a need for alternative solutions that can target both resistant and susceptible strains.

Innovation Solution

A pesticidal mixture comprising one or more milbemycins, such as moxidectin, combined with one or more pyrethroids like permethrin or pyrethrum, optionally with C8, 9, 10 fatty acids, is applied to achieve high mortality rates in arthropods, including resistant strains.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If pyrethroids are used to control arthropod populations, then arthropod mortality is achieved, but resistance develops in arthropod populations rendering the insecticide ineffective

Engineering Contradiction:

Improveinsecticide effectivenessVSAvoidarthropod resistance

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines pyrethroids with milbemycins in a single insecticide formulation. This merging of two different insecticide classes with different modes of action creates a synergistic effect that controls arthropods while reducing the development of resistance. The pyrethroid component provides rapid knockdown while the milbemycin component contributes to sustained mortality and resistance management.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite insecticide material consisting of multiple chemical compounds from different classes (pyrethroids and milbemycins). This composite formulation leverages the complementary properties of each component to achieve superior arthropod control and delay resistance development compared to single-component insecticides.

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If single-class insecticides are used, then application is simple, but resistance develops and control effectiveness decreases over time

Engineering Contradiction:

Improveinsecticide application simplicityVSAvoidpest control effectiveness

Core Design Contradiction:

Ease of operationVSProductivity

Solution Approach 1:

The patent merges pyrethroid and milbemycin components into a single insecticide product that maintains ease of application while enhancing control effectiveness. The combination allows for simplified application protocols compared to sequential applications of single-class insecticides, yet achieves superior and more sustained pest control results.

Inventive Principle:

Principle #5Merging (Combining)

3Reliability

If pyrethroid-resistant arthropod strains are present, then pyrethroid alone becomes ineffective, but combination with milbemycin restores control capability

Engineering Contradiction:

Improvecontrol against resistant strainsVSAvoidefficacy across different arthropod populations

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent creates a universal insecticide formulation that effectively controls both pyrethroid-susceptible and pyrethroid-resistant arthropod strains. The milbemycin component provides activity against resistant strains while the pyrethroid component maintains effectiveness against susceptible strains, making the formulation adaptable to diverse arthropod populations with varying resistance levels.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination of milbemycins and pyrethroids demonstrates enhanced efficacy in controlling mosquito populations, providing unexpected levels of control even against strains resistant to pyrethroids or milbemycins alone, with improved mortality rates and residual effects.

Implementation Method 1

Pyrethroids are axonic excitotoxins which prevent the closure of the voltage-gated sodium channels in the axonal membranes of arthropods. The toxins work by paralyzing the organism.

Methodology Applied

Scientific EffectAxonic excitotoxin mechanism:

Implementation Method 2

Milbemycins are macrocyclic lactones that are generated as fermentation products of Streptomyces. Natural milbemycins and synthetic derivatives thereof are known to control helminths and insects.

Methodology Applied

Scientific EffectMacro cyclic lactone toxicity:

Data Source

PatentUS20230110595A1Mixture of pyrethroids and milbemycins and uses thereof

Publication Date: 2023.04.13 VALENT BIOSCIENCES CORP

AI summary

The present invention is directed to a pesticidal mixture comprising one or more milbemycins and one or more pyrethroids. The present invention is further directed to a method of controlling pests comprising applying a mixture of the present invention to an area in need of pest control.