Milk And Egg Phospholipid Composition for Bioavailable Choline
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Solution Overview
Problem
Existing nutritional compositions fail to provide high bioavailability of choline, essential for infant, pregnant woman, and elderly nutrition, as choline salts are not readily absorbed, and existing infant formulas do not replicate the choline levels found in human breast milk.
Innovation Solution
A nutritional composition combining milk and egg phospholipids, optionally with vegetable phospholipids, to provide a high level of phosphatidylcholine and sphingomyelin, ensuring choline is bound to phospholipids for improved bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If choline salts are added to nutritional composition to meet choline requirements, then choline content is sufficient, but bioavailability is poor and absorption is not ready
Solution Approach 1:
The patent changes the chemical form of choline from salt form to phospholipid-bound form (specifically phosphatidylcholine and sphingomyelin). This parameter change in the molecular structure and binding state of choline transforms it from a poorly absorbable salt into a highly bioavailable phospholipid compound that mimics human breast milk composition.
Solution Approach 2:
The patent combines choline with phospholipids (phosphatidylcholine and sphingomyelin) to create a composite nutritional material. This composite approach integrates choline into a phospholipid matrix, enhancing its bioavailability while maintaining adequate choline content for nutritional requirements.
2Quantity of substance
If conventional infant formulas are used to provide choline, then choline content can be adjusted, but they fail to replicate the choline levels and bioavailability found in human breast milk
Solution Approach 1:
The patent copies the natural composition of human breast milk by incorporating phospholipid-bound choline (phosphatidylcholine and sphingomyelin) in proportions and forms that replicate breast milk's choline profile. This copying approach ensures both adequate choline levels and high bioavailability matching natural breast milk.
Solution Approach 2:
The patent changes the form of choline from conventional salt forms to phospholipid-bound forms, specifically matching the parameters of choline binding and molecular structure found in human breast milk, thereby achieving both appropriate quantity and high bioavailability.
3Reliability
If phospholipid-bound choline is used instead of choline salts, then bioavailability is improved, but formulation complexity increases
Solution Approach 1:
The patent uses phospholipids that serve multiple functions: they provide structural components for cell membranes, act as emulsifiers in the nutritional composition, and serve as carriers for choline delivery. This multi-functionality reduces formulation complexity despite using phospholipid-bound choline.
Data Source
AI summary
The present invention provides a nutritional composition especially well suited as an infant nutritional composition especially well suited as an infant nutritional composition, but also as a nutritional support product for pregnant women and as senior nutritional supplement, where phosphatidylcholine and sphingomyelin, and thus choline, also are highly relevant. The present invention provides a nutritional composition which contains choline of high bio-availability.