Milk Microvesicle Supplementation for Infant Formula miRNA Delivery
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Solution Overview
Problem
Infant formulas lack the beneficial microvesicles and miRNA molecules present in natural milk, which are essential for providing protective and therapeutic effects against infections, inflammations, and cancers.
Innovation Solution
Incorporating microvesicles derived from milk, specifically exosomes and fat globules, into infant formulas to supplement their nutritional content with miRNA molecules such as miR-148a, which can be isolated using a cost-effective and efficient centrifugation method, ensuring their stability and biological activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If infant formulas are designed to be artificial and simplified for manufacturing, then ease of manufacture is improved, but the presence of beneficial microvesicles and miRNA molecules is lost
Solution Approach 1:
The patent extracts microvesicles containing miRNA molecules from natural milk sources and incorporates them into infant formula. This extraction approach allows the formula to gain the beneficial biological components while maintaining the simplicity and manufacturability of artificial formula, resolving the contradiction between ease of manufacture and presence of beneficial substances.
2Quantity of substance
If natural milk components are included in infant formulas, then the presence of beneficial microvesicles and miRNA molecules is improved, but device complexity and manufacturing difficulty increase
Solution Approach 1:
The patent creates a simplified version of natural milk by extracting and incorporating only the essential microvesicles and miRNA molecules into infant formula. This copying approach replicates the beneficial effects of natural milk without requiring the complexity of producing or handling complete natural milk, thus reducing device complexity while maintaining the presence of beneficial substances.
3Reliability
If microvesicles are added to infant formulas to provide therapeutic effects, then reliability and health benefits are improved, but manufacturing precision and quality control become more difficult
Solution Approach 1:
The patent optimizes parameters such as centrifugation speed, temperature, and pH to ensure stable extraction and incorporation of microvesicles into infant formula. By controlling these parameters, the patent achieves consistent therapeutic effects while maintaining manageable manufacturing precision requirements, resolving the contradiction between reliability and manufacturing precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The addition of milk-derived microvesicles to infant formulas enhances their ability to prevent and treat conditions like infections and cancers by providing the missing miRNA molecules, improving infant health and immune system development.
Implementation Method 1
a cost-effective and efficient centrifugation method
Data Source
AI summary
Provided are microvesicles isolated from milk, compositions thereof and uses for the preparation of milk formulas. Further provided are microvesicles, including exosomes and/or fat globules which encapsulate various miRNA molecules and uses thereof, as exemplified by supplementing milk formulas.