Milk Replacer Halides Hydrogen Peroxide Antimicrobial

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Solution Overview

Problem

Existing milk replacers for young livestock lack effective antimicrobial properties and are costly to produce, as they require active lactoperoxidase systems which are challenging to maintain and have scarce component availability.

Innovation Solution

Milk replacers containing halides and sources of hydrogen peroxide, which can be produced using traditional methods without an active lactoperoxidase system, are fed to young animals to enhance performance, with the halides and hydrogen peroxide sources improving weight gain and feed efficiency.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If an active lactoperoxidase system is used in milk replacers to provide antimicrobial properties, then the antimicrobial effectiveness is improved, but the production cost increases and component availability becomes scarce

Engineering Contradiction:
Improveantimicrobial effectivenessVSAvoidproduction cost and component availability
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The patent extracts the essential antimicrobial function from the complex active lactoperoxidase system and implements it through separate, stable components (halides and hydrogen peroxide sources) that can be independently produced and combined, eliminating the need for expensive and scarce LP system components while maintaining antimicrobial effectiveness

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent changes the chemical parameters by using halides (such as iodide) and hydrogen peroxide sources instead of the protein-based lactoperoxidase system, transforming the antimicrobial mechanism from enzyme-catalyzed to chemical oxidation while achieving the same protective effect at lower cost

Inventive Principle:
Principle #35Parameter changes

2Reliability

If time-temperature treatments are controlled during replacer manufacture to preserve the LP system, then the antimicrobial properties are maintained, but the manufacturing complexity and challenges increase

Engineering Contradiction:
Improveantimicrobial propertiesVSAvoidmanufacturing process complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

Instead of trying to preserve the heat-sensitive lactoperoxidase enzyme through careful time-temperature control, the patent inverts the approach by using heat-stable chemical components (halides and hydrogen peroxide sources) that achieve the same antimicrobial effect without requiring complex temperature management during manufacturing

Inventive Principle:
Principle #13The other way round (Inversion)

3Reliability

If milk replacers contain components capable of sustaining the LP active system (whey protein, casein, whey protein concentrate, skim milk), then the LP system remains active, but the availability of these components becomes scarce

Engineering Contradiction:
ImproveLP system activityVSAvoidcomponent availability
Core Design Contradiction:
ReliabilityVSQuantity of substance

Solution Approach 1:

The patent extracts the antimicrobial function from the protein matrix required to sustain lactoperoxidase activity and implements it through standalone chemical components (halides and hydrogen peroxide sources) that do not require scarce dairy protein ingredients, thereby ensuring consistent availability

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent replaces expensive, scarce dairy protein components with more readily available and cost-effective chemical substances (halides and peroxide sources) that can be easily sourced and do not depend on limited dairy ingredient supplies

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination of halides and hydrogen peroxide in milk replacers increases starter feed intake and weight gain in young animals, reducing the feed-to-gain ratio and improving overall performance without the need for active lactoperoxidase systems, thus addressing the cost and availability issues of traditional methods.

Implementation Method 1

a source of hydrogen peroxide, such as hydrogen peroxide or percarbonate, which reduces into hydrogen peroxide

Methodology Applied
Scientific EffectReduction: Reduction

Data Source

PatentUS11213051B2Milk replacer products containing halides and sources of hydrogen peroxide and methods of feeding same
Publication Date: 2022.01.04 PURINA ANIMAL NUTRITION LLC
  • US11213051B2 patent drawing

AI summary

Methods involve feeding young animals milk products containing milk-based protein, a halide and a source of hydrogen peroxide, where an active lactoperoxidase system is not present in the milk product fed to the young animal, in response to ingesting the milk product, the young animal decreases a feed to gain ratio. Milk replacers may be provided as the milk product, and the young animals may be calves. Milk replacers contain milk-derived protein, a source of hydrogen peroxide at about 50 to about 500 parts per million by weight of the rehydrated milk replacer and iodide at about 1 to about 50 parts per million by weight of the rehydrated milk replacer, where an active lactoperoxidase system is not present.