Milk Thistle Flower Extract Composition for Cell Senescence
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Solution Overview
Problem
Existing hair loss treatments, particularly chemical agents, are ineffective when discontinued and have side effects, while natural alternatives are needed to address hair loss caused by dermal papilla cell senescence.
Innovation Solution
A composition containing a milk thistle flower extract is used to promote dermal papilla cell proliferation and activate dermal papilla cells by inhibiting senescence-associated β-galactosidase and senescence-associated secretory phenotypes, providing a safe and effective natural anti-hair loss agent.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If chemical anti-hair loss agents are used continuously, then hair loss prevention effect is maintained, but side effects such as dermatitis, decreased libido, and gynecomastia occur
Solution Approach 1:
The patent changes the chemical composition parameters by using natural milk thistle flower extract instead of synthetic chemical agents, maintaining the hair loss prevention function while eliminating harmful side effects through natural ingredient selection
Solution Approach 2:
The patent employs a natural extract that can be discontinued without accumulating harmful effects in the body, unlike chemical agents that require continuous use to maintain effect and can cause long-term side effects
2Object-affected harmful factors
If chemical anti-hair loss agents are stopped, then side effects are avoided, but hair loss prevention effect is lost
Solution Approach 1:
The natural milk thistle flower extract works through biological mechanisms that can be sustained through regular use without requiring continuous high-dose chemical intervention, allowing for a more sustainable treatment approach that can be adjusted or discontinued with less risk of effect loss
3Object-affected harmful factors
If natural anti-hair loss agents are used, then side effects are reduced, but effectiveness and safety need to be verified
Solution Approach 1:
The patent replaces the need for extensive clinical trial verification with in vitro studies using dermal papilla cells and biochemical assays to demonstrate mechanism of action, showing that the natural extract inhibits SA-β-Gal activity and promotes cell proliferation in a controlled laboratory setting
Data Source
AI summary
The present invention relates to a composition for preventing hair loss or promoting hair growth containing a milk thistle flower extract as an active ingredient. More specifically, the present invention relates to a cosmetic composition, pharmaceutical composition and food composition containing a milk thistle flower extract as an active ingredient, which are able to promote hair growth by inducing the proliferation of dermal papilla cells reduced due to senescence, and activate dermal papilla cells by inhibiting the senescence of dermal papilla cells through inhibition of the activity of senescence-associated β-galactosidase (SA-β-Gal) and the production of senescence-associated secretory phenotypes, thereby preventing hair loss or promoting hair.The composition according to the present invention has no skin irritation and cytotoxicity, and thus has excellent safety for the human body, and at the same time, is very effective in promoting the proliferation of dermal papilla cells and inhibiting the senescence of dermal papilla cells. Thus, it may be useful as an active ingredient in a cosmetic composition, a pharmaceutical composition or a food composition for preventing hair loss or promoting hair growth.