Mineral-Coated Microparticles for Localized Sustained Biologic Release
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Solution Overview
Problem
Current delivery strategies for biologically active agents, such as IL-1 receptor antagonist (IL-Ra), suffer from short in vivo half-life and high doses, leading to reduced activity and the need for frequent injections, while encapsulation methods impair protein function and require higher doses.
Innovation Solution
A formulation using mineral coated microparticles that adsorb and/or incorporate biologically active agents, allowing for sustained and localized delivery through a mineral coating that degrades over time, maintaining therapeutic concentrations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If encapsulation methods are used to deliver active agents, then localized delivery is achieved, but protein function is impaired and higher doses are required
Solution Approach 1:
The patent uses mineral coated microparticles as an intermediary carrier system. The microparticles adsorb the active agent (IL-Ra) onto their surface through mineral coating, serving as a mediator that delivers the protein without impairing its function. This resolves the contradiction by providing localized delivery while preserving protein activity, eliminating the need for higher doses.
2Duration of action of moving object
If conventional delivery strategies are used, then active agents are administered, but short in vivo half-life requires frequent injections
Solution Approach 1:
The patent applies preliminary action by pre-coating the microparticles with mineral layers before introducing the active agent. This preliminary mineral coating creates a sustained release framework that gradually degrades over time, extending the in vivo half-life of the active agent and reducing the frequency of injections required to maintain therapeutic levels.
3Reliability
If higher doses of active agents are used, then therapeutic effect is achieved, but reduced activity and increased cost occur
Solution Approach 1:
The patent changes the physical and chemical parameters of the delivery system by using mineral coated microparticles with specific surface properties. The mineral coating alters the interaction between the active agent and the body, extending half-life and maintaining therapeutic concentrations with lower doses, thereby improving reliability while reducing quantity required.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The mineral coated microparticles provide sustained release of active agents, maintaining therapeutic levels for extended periods, enhancing biological activity and reducing the frequency of injections.
Implementation Method 1
mineral coated microparticles that adsorb and/or incorporate biologically active agents
Implementation Method 2
through a mineral coating that degrades over time, maintaining therapeutic concentrations
Data Source
AI summary
Disclosed are formulations for providing an active agent. Formulations include a carrier including an active agent and mineral coated microparticles wherein an active agent is adsorbed to the mineral. Other formulations include a carrier including mineral coated microparticles wherein mineral coated microparticles include an active agent. Also disclosed are methods for sustained delivery of an active agent and methods for treating inflammatory diseases using a formulation for providing sustained delivery of an active agent.