Modified-Release Minoxidil Composition for Steady Oral Absorption

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing formulations of minoxidil for treating hair loss do not provide controlled release profiles, leading to variable absorption and potential adverse effects due to peak serum concentrations.

Innovation Solution

A modified release formulation of minoxidil that releases 50% to 98% of the daily dose within 12 hours, with a Tmax of 30 to 360 minutes and Cmax of 0.25 ng/ml to 20 ng/ml, designed for oral administration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Speed

If immediate release formulation of minoxidil is used, then rapid drug absorption occurs, but peak serum concentrations cause adverse effects

Engineering Contradiction:

Improvedrug absorption speedVSAvoidadverse effects from peak serum concentrations

Core Design Contradiction:

SpeedVSObject-affected harmful factors

Solution Approach 1:

The patent applies dynamic release by designing a modified release formulation that adjusts the rate of minoxidil release over time, transitioning from initial release to sustained release, thereby avoiding peak serum concentrations while maintaining therapeutic efficacy

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The patent changes the release rate parameter of minoxidil from immediate to modified release, controlling the concentration-time profile to maintain levels within therapeutic range without exceeding thresholds that cause adverse effects

Inventive Principle:

Principle #35Parameter changes

2Duration of action of moving object

If immediate release formulation of minoxidil is used, then quick therapeutic effect is achieved, but variable absorption reduces reliability

Engineering Contradiction:

Improveduration of therapeutic effectVSAvoidconsistency of drug absorption

Core Design Contradiction:

Duration of action of moving objectVSReliability

Solution Approach 1:

The patent ensures continuous therapeutic action by designing a modified release formulation that provides sustained minoxidil release over an extended period, maintaining consistent plasma concentrations and eliminating the variability associated with immediate release formulations

Inventive Principle:

Principle #20Continuity of useful action

3Stability of the object's composition

If modified release formulation is designed, then controlled release profile is achieved, but formulation complexity increases

Engineering Contradiction:

Improvecontrolled release profileVSAvoidformulation complexity

Core Design Contradiction:

Stability of the object's compositionVSDevice complexity

Solution Approach 1:

The patent achieves controlled release by modifying the physical or chemical parameters of the formulation, such as using specific polymers or matrix materials that control drug release kinetics, rather than complex mechanical structures

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS20260053800A1Compositions and methods of use for modified release minoxidil

Publication Date: 2026.02.26 VERADERMICS INC

AI summary

The compositions and methods provided herein include a pharmaceutical formulation for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Also provided herein are pharmaceutical formulations for oral administration comprising a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof and one or more additional active agents. Also provided herein are methods of treating hair loss by administering to a subject in need thereof a daily dose of a modified release formulation of minoxidil or a pharmaceutically acceptable salt thereof. Further provided herein is a kit including a slow modified release vehicle comprising oral minoxidil or a pharmaceutically acceptable salt thereof.