Mite Allergen Composition for Precise Sensitization Pattern Diagnosis
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Solution Overview
Problem
Current diagnostic methods for allergies to house dust mites are not precise, leading to inadequate identification of sensitization patterns, which affects the accuracy of diagnosis and treatment, particularly for allergen-specific immunotherapy.
Innovation Solution
A composition and kit that include specific mite allergens such as Der f 11, Der f 13, Der f 14, Der f 32, and Der f Alt a 10, or combinations thereof, which are used to diagnose and potentially treat mite allergies by examining IgE reactivities in biological samples, allowing for more accurate prediction of allergic diseases and immunotherapy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If current diagnostic methods are used for mite allergies, then general diagnosis can be performed, but precise identification of sensitization patterns cannot be achieved
Solution Approach 1:
The patent segments the diagnostic approach by dividing mite allergens into specific component allergens (Der f 1, Der f 2, Der f 10, etc.). Instead of using a single general mite extract, the composition contains multiple purified component allergens that can be individually detected to identify specific sensitization patterns, thereby improving diagnostic precision without excessive complexity
Solution Approach 2:
The patent applies local quality by providing different diagnostic information through specific component allergens. Each component allergen in the composition targets specific aspects of mite sensitization, allowing the diagnostic system to identify precise sensitization patterns (e.g., sensitization to Der f 1 but not Der f 2) rather than general mite allergy only
2Loss of information
If general mite allergen detection is performed, then broad allergy screening is possible, but accurate identification of specific sensitization patterns is lost
Solution Approach 1:
The composition segments mite allergens into distinct component allergens (Der f 1, Der f 2, Der f 10, Der p 1, Der p 2, Der p 10). This segmentation preserves sensitization pattern information by enabling detection of which specific components the patient is sensitized to, rather than providing only a general positive/negative result from a mixed extract
Solution Approach 2:
The composition achieves multi-functionality by containing multiple component allergens from different mite species (Dermatophagoides farinae and Dermatophagoides pteronyssinus). This single composition can simultaneously screen for sensitization to various mite species and identify specific sensitization patterns, reducing the need for multiple separate tests
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables precise identification of allergen sensitization patterns, improving diagnostic accuracy and enabling targeted immunotherapy, thereby enhancing treatment outcomes for mite allergy patients.
Implementation Method 1
A composition and kit that include specific mite allergens such as Der f 11, Der f 13, Der f 14, Der f 32, and Der f Alt a 10, or combinations thereof, which are used to diagnose and potentially treat mite allergies by examining IgE reactivities in biological samples
Data Source
AI summary
Mite proteins according to an aspect may be used in diagnosing allergic diseases. Results of diagnosing allergic diseases by using the proteins have high reliability and validity. Further, the proteins may be used in a composition for preventing or treating allergic diseases.