Mitophagy-Stimulating Skin Care Composition for Cellular Aging

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Solution Overview

Problem

Existing skin care compositions fail to effectively combat the effects of oxidative stress and mitochondrial dysfunction, leading to visible signs of aging such as wrinkles and hyperpigmented spots, by not addressing the critical quality control process of mitophagy in skin cells.

Innovation Solution

A skin care composition containing bioactive materials that stimulate mitophagy in human skin cells, restoring functional mitophagy to prevent and reverse cellular aging phenotypes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional skin care compositions are used, then basic skin maintenance is provided, but they fail to combat oxidative stress and mitochondrial dysfunction leading to visible aging signs

Engineering Contradiction:

Improveeffectiveness in combating agingVSAvoidoxidative stress and mitochondrial dysfunction

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies parameter changes by modifying the biochemical parameters of skin cells through targeted delivery of actives that alter mitochondrial function and oxidative stress levels. Specifically, the composition changes the mitophagy rate, ROS production levels, and mitochondrial membrane potential to reverse aging phenotypes.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses bioactive materials as intermediaries to transfer the anti-aging effect from the topical composition to the mitochondrial machinery. These actives (e.g., STOCKIN-57543, hydroxycinnamic acids) serve as mediators that stimulate mitophagy and restore mitochondrial quality control processes.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Object-affected harmful factors

If skin cells are exposed to stressors like UV radiation and pollution, then ROS production increases causing cellular damage, but the cell's natural defenses become overwhelmed leading to chronic alterations

Engineering Contradiction:

ImproveROS productionVSAvoidcellular homeostasis

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent applies preliminary action by pre-stimulating mitophagy and enhancing mitochondrial quality control mechanisms before oxidative stress becomes chronic. The composition is applied proactively to maintain mitochondrial health and prevent the accumulation of ROS that would otherwise overwhelm cellular defenses.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent converts the harmful effect of ROS by using it as a signaling stimulus to trigger enhanced mitophagy. The composition leverages mild oxidative stress signals to activate protective pathways that ultimately reduce ROS accumulation and clear damaged mitochondria.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Reliability

If mitophagy is stimulated in skin cells, then cellular aging phenotypes are reversed and skin health improves, but specific bioactive materials are required to target mitochondrial pathways

Engineering Contradiction:

Improvemitophagy stimulationVSAvoidcomposition formulation

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies universality by developing a composition platform that can deliver multiple anti-aging benefits through a single primary mechanism (mitophagy stimulation). The same bioactive materials target multiple age-related issues including wrinkles, hyperpigmentation, and loss of firmness by restoring mitochondrial function across different skin cell types.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentUS20250381110A1Skin care composition and method of using the same

Publication Date: 2025.12.18 PROCTER & GAMBLE CO

AI summary

A skin care composition that includes bioactive materials, other optional skin ingredients. and a dermatologically acceptable carrier. The materials stimulate mitophagy and prevent or reverse cellular aging to help improve skin health and appearance.