Mitral Valve Annulus Reshaping via Endovascular Wire Anchoring
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Solution Overview
Problem
Current treatments for mitral valve regurgitation often require open-heart surgery and have limited success in effectively increasing leaflet coaptation, leading to suboptimal results and higher mortality rates compared to endovascular techniques.
Innovation Solution
The use of endovascular devices, including wires anchored to the mitral annulus and fibrous trigon, to reshape the mitral valve annulus by reducing the distance between the anterior and posterior leaflets, thereby enhancing coaptation and reducing regurgitation through a minimally invasive procedure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If open-heart surgery is used to treat mitral valve regurgitation, then leaflet coaptation can be effectively increased, but the procedure has higher mortality rates and longer hospitalization time
Solution Approach 1:
The patent replaces the mechanical open-heart surgery system with an endovascular device system that uses catheter-based delivery and wire manipulation to achieve annulus reshaping and leaflet coaptation enhancement without requiring chest opening and cardiopulmonary bypass
Solution Approach 2:
The patent introduces anchoring elements as intermediaries that are positioned within the mitral annulus and connected to external wires, allowing force transmission and annulus reshaping without direct surgical intervention on the heart structure
2Reliability
If open-heart surgery is used to treat mitral valve regurgitation, then leaflet coaptation can be effectively increased, but the procedure carries higher mortality rates
Solution Approach 1:
The patent replaces the high-risk open-heart surgical system with a lower-risk endovascular system that avoids sternotomy, cardiopulmonary bypass, and direct heart manipulation, thereby reducing mortality risk while maintaining therapeutic effectiveness
Solution Approach 2:
The patent enables the heart valve to self-correct its dysfunction through endovascularly deployed anchoring elements that reshape the annulus and improve coaptation, eliminating the need for complex surgical interventions and reducing associated mortality risks
3Ease of operation
If endovascular devices are used to reshape the mitral valve annulus, then the procedure is minimally invasive with reduced hospitalization time, but the device complexity increases
Solution Approach 1:
The patent divides the endovascular device into separate functional components including delivery catheter, anchoring elements, and manipulation wires, allowing each component to be optimized independently and simplifying the overall system architecture despite the minimally invasive requirement
Solution Approach 2:
The patent designs anchoring elements that serve multiple functions: providing structural support for annulus reshaping, serving as attachment points for wires, and enabling positional adjustment, thereby reducing the number of separate components needed and managing device complexity
Data Source
AI summary
Devices and methods are disclosed for treating mitral valve regurgitation that include members that assist the valve in closing during the cardiac cycle. Such devices may include members configured to alter the shape of mitral valve annulus. In certain embodiments, one or more wires may be anchored on one extremity to an element positioned along the posterior part of the mitral annulus, in the coronary sinus, and on another extremity to an element along the anterior part of the mitral annulus, fibrous trigon. The reshaping of the mitral annulus may be accomplished by pulling the wire or wires. Reducing the length of the wire or wires may provide the displacement of the posterior leaflets towards the anterior, thereby increasing the coaptation surface for the valve leaflets and reducing the regurgitation.