Sequentially Deployed Mitral Valve Prosthesis Anchoring
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Solution Overview
Problem
Current treatments for mitral valve regurgitation, such as surgical implantation and minimally invasive catheter techniques, face challenges in accurately positioning and securely anchoring prosthetic valves, leading to varying clinical results and recovery times.
Innovation Solution
A prosthetic valve with an expandable frame and tabs that self-expand to engage the mitral valve leaflets and chordae tendineae, using a delivery system that allows sequential deployment of the anterior and posterior tabs and skirts to securely anchor the valve, while also optionally carrying therapeutic agents for tissue integration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional surgical implantation methods are used, then secure anchoring of prosthetic valve is achieved, but invasiveness and recovery time increase
Solution Approach 1:
The prosthetic valve is divided into multiple deployable components including anterior tabs, posterior tabs, and a skirt that can be sequentially deployed from a compressed state within a delivery catheter to an expanded anchored state, allowing minimally invasive delivery while achieving secure anchoring
Solution Approach 2:
The prosthetic valve components are nested within a delivery catheter in a compressed configuration during delivery, then expanded at the implantation site to achieve their functional anchored configuration, enabling minimally invasive access while maintaining anchoring capability
2Object-affected harmful factors
If minimally invasive catheter techniques are used, then invasiveness is reduced, but positioning accuracy and anchoring security decrease
Solution Approach 1:
The prosthetic valve components are pre-configured with specific geometries and expansion characteristics that enable them to automatically assume their correct positioned and anchored configuration upon deployment, ensuring positioning accuracy without requiring complex steering mechanisms
Solution Approach 2:
The prosthetic valve components are designed to self-expand and self-anchor upon deployment from the delivery catheter, with the tabs and skirt automatically engaging the native valve structure to achieve secure anchoring without requiring additional steering or positioning maneuvers
3Productivity
If prosthetic valve components are deployed simultaneously, then deployment speed is increased, but control over anchoring sequence is lost
Solution Approach 1:
The prosthetic valve is segmented into multiple independently deployable components (anterior tabs, posterior tabs, skirt) that can be released in a controlled sequence from the delivery catheter, allowing the operator to control the anchoring sequence while maintaining efficient deployment
Solution Approach 2:
The delivery catheter system incorporates dynamic control mechanisms that allow the operator to control the timing and sequence of component deployment, enabling staged expansion and anchoring of the prosthetic valve components in a controlled manner
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables more accurate and secure anchoring of the prosthetic valve, reducing mitral regurgitation and allowing for a potentially less invasive procedure with improved clinical outcomes.
Implementation Method 1
The self-expanding frame has an expanded configuration and a collapsed configuration. The expanded configuration is adapted to engage heart tissue, and the collapsed configuration is adapted to be delivered to a patient's heart.
Data Source
AI summary
A sequentially deployed prosthetic cardiac valve includes a self-expanding frame having an atrial skirt, a ventricular skirt, and an annular region disposed therebetween. A first anterior tab is disposed on an anterior portion of the frame. A posterior tab is on a posterior portion of the self-expanding frame. The frame may be designed so that any portion may expand sequentially in any desired order. For example, a portion of the first anterior tab and a portion of the posterior tab may partially self-expand first. Next, the first anterior tab may fully self-expand before the posterior tab fully self-expands. The posterior tab may fully self-expand next followed by the ventricular skirt, or the ventricular skirt may self-expand next followed by full expansion of the posterior tab.