Mitral Valve Prosthesis Delivery for Preserving Leaflet Function
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Solution Overview
Problem
Current surgical treatments for mitral valve regurgitation, such as mitral valve replacement and repair, face challenges with durability issues for bioprosthetics, require anticoagulation for mechanical valves, and alter the mitral valve's natural function by fixing the posterior leaflet in a closed position.
Innovation Solution
A tether delivery catheter for anchoring tethers to anatomical locations, a prosthesis delivery system with expandable chambers, and a lock deployment catheter for securing prostheses, allowing minimally invasive mitral valve repair and replacement with adjustable prostheses that maintain natural leaflet function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If mitral valve replacement with bioprosthetic valve is performed, then valve function is restored, but long-term durability is poor
Solution Approach 1:
The prosthesis is designed with adjustable components that allow dynamic modification of valve geometry and leaflet positioning after implantation. The adjustment mechanism enables the prosthesis to adapt to changing physiological conditions and achieve optimal function over time, thereby improving long-term durability while maintaining restored valve function.
Solution Approach 2:
The invention allows modification of critical parameters including leaflet coaptation depth, annulus diameter, and leaflet orientation through post-implantation adjustment. By changing these parameters, the prosthesis can optimize its performance characteristics to enhance durability while maintaining the restored valve function.
2Reliability
If mitral valve replacement with mechanical valve is performed, then valve function is restored, but anticoagulation is required
Solution Approach 1:
The prosthesis utilizes a biocompatible frame structure with flexible leaflets that can be adjusted and replaced if necessary. The design incorporates disposable or replaceable components that can be modified without requiring systemic anticoagulation, thereby eliminating the harmful anticoagulation requirement while maintaining restored valve function.
3Reliability
If mitral annuloplasty is performed to reduce annulus circumference, then mitral valve competence is improved, but posterior leaflet mobility is restricted
Solution Approach 1:
The prosthesis incorporates an adjustable annulus reduction mechanism that allows dynamic modification of the annulus circumference while preserving posterior leaflet mobility. The adjustable components enable the posterior leaflet to move naturally during the cardiac cycle, maintaining ease of operation while achieving improved mitral valve competence through controlled annulus reduction.
4Reliability
If surgical mitral valve repair is performed, then mitral valve competence is achieved, but surgical invasiveness is high
Solution Approach 1:
The prosthesis serves as an intermediary device that can be delivered through minimally invasive catheter-based approaches. The delivery system allows the complex prosthesis with multiple adjustment mechanisms to be implanted through small access points, thereby reducing surgical invasiveness while achieving mitral valve competence through the prosthesis's structural support and adjustment capabilities.
Data Source
AI summary
The disclosure provides systems and related methods for delivering a prosthesis to a target location. The system includes a tether delivery catheter and a prosthesis delivery catheter, and also can include a lock delivery catheter or knot pusher, as desired. Various embodiments of useful valve prostheses are also disclosed.