Mixed Allergen Compositions for Broad-Spectrum Immune Modulation

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Solution Overview

Problem

Current treatments for food allergies often rely on single protein allergens, which may not effectively inhibit symptoms or reduce the risk of developing allergies, as they fail to provide broad-spectrum protection against multiple allergens, leading to significant healthcare costs and risks, including anaphylactic reactions.

Innovation Solution

Mixed allergen compositions comprising two or more different allergens, including nut, animal, and non-nut plant allergens, along with biotic agents and vitamins, are administered to subjects to treat and prevent food allergies by modulating the immune response, reducing Th2 cell proliferation, and increasing IgG4 levels, thereby achieving immune balance and gut health.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If single protein allergen treatments are used, then the treatment formulation is simple, but the effectiveness in inhibiting food allergy symptoms and reducing allergy risk is insufficient

Engineering Contradiction:

Improveeffectiveness in inhibiting food allergy symptomsVSAvoidtreatment formulation complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines multiple different allergens (nut allergens, animal allergens, plant allergens) into a single mixed allergen composition that is administered together. This merging of multiple allergen components into one treatment formulation allows the composition to provide broad-spectrum protection against various food allergens simultaneously, resolving the contradiction by improving effectiveness while maintaining formulation simplicity through combination rather than separate treatments.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The mixed allergen composition is designed to serve multiple functions: it treats existing food allergies, prevents development of new allergies, and provides broad-spectrum protection against various allergen types (nuts, animals, plants). This multi-functionality allows a single treatment composition to address diverse allergy scenarios, improving reliability of allergy inhibition while avoiding the need for multiple specialized formulations.

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Adaptability or versatility

If single protein allergen treatments are used, then the manufacturing process is simple, but the protection against multiple allergens is limited

Engineering Contradiction:

Improveprotection against multiple allergensVSAvoidmanufacturing process complexity

Core Design Contradiction:

Adaptability or versatilityVSEase of manufacture

Solution Approach 1:

Multiple allergen sources (nut, animal, plant) are merged into a single mixed composition that can be manufactured as one product. This approach provides adaptability and versatility in protecting against multiple allergen types while streamlining the manufacturing process compared to producing and managing separate single-allergen formulations, thereby resolving the contradiction between versatility and ease of manufacture.

Inventive Principle:

Principle #5Merging (Combining)

3Object-affected harmful factors

If conventional allergy treatments are used, then the healthcare cost is reduced, but the risk of anaphylactic reactions remains significant

Engineering Contradiction:

Improverisk of anaphylactic reactionsVSAvoidhealthcare cost

Core Design Contradiction:

Object-affected harmful factorsVSLoss of energy

Solution Approach 1:

The mixed allergen composition is administered proactively to induce regulatory T cell responses and IgG4 antibody production before allergen exposure occurs. This preliminary anti-action creates a protective immune state that prevents anaphylactic reactions from occurring in the first place, rather than merely treating symptoms after they manifest, thereby reducing both the risk of severe reactions and associated healthcare costs.

Inventive Principle:

Principle #9Preliminary anti-action

Solution Approach 2:

The patent converts the potentially harmful allergen proteins into beneficial regulatory molecules that induce tolerance. By administering controlled amounts of allergen proteins, the immune system is guided to produce protective IgG4 antibodies and regulatory T cells, transforming the allergen from a harmful trigger into a therapeutic agent that prevents future allergic reactions and reduces healthcare burden.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Data Source

PatentUS10525125B2Mixed allergen compositions and methods for using the same

Publication Date: 2020.01.07 THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV

AI summary

Mixed allergen compositions of one, two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.