Mixed Liquid Chamber Neutralization in Automated Analyzers

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Solution Overview

Problem

Existing automatic analyzers face issues where residual reagents in the mixed liquid chamber affect the creation of new mixed liquids, leading to inaccurate analysis results.

Innovation Solution

The automatic analyzer introduces a relaxation reagent into the mixed liquid chamber based on the characteristics of the residual reagent, neutralizing or diluting its effects to ensure accurate subsequent processes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If a new mixed liquid is created in the mixed liquid chamber, then the analysis process can proceed, but the residual liquid from the previous mixed liquid affects the accuracy of the new analysis

Engineering Contradiction:
Improveanalysis throughputVSAvoidanalysis accuracy
Core Design Contradiction:
ProductivityVSMeasurement precision

Solution Approach 1:

The relaxation reagent is introduced into the mixed liquid chamber before the new reagent to pre-neutralize the residual liquid from the previous analysis. This preliminary action ensures that when the new reagent is introduced, the chamber is already in a state that will not interfere with the new analysis, thus maintaining high accuracy without sacrificing throughput

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The relaxation reagent acts as an intermediary substance between the residual liquid from the first mixed liquid and the new reagent. It chemically neutralizes the residual liquid's effects, creating a neutral environment that allows the new reagent to function accurately without interference from previous substances

Inventive Principle:
Principle #24Intermediary (Mediator)

2Loss of time

If the mixed liquid chamber is not thoroughly cleaned between analyses, then the analysis process is faster, but the residual reagent contaminates the next analysis

Engineering Contradiction:
Improvetime between analysesVSAvoidresidual reagent contamination
Core Design Contradiction:
Loss of timeVSObject-affected harmful factors

Solution Approach 1:

The relaxation reagent serves as a chemical intermediary that neutralizes residual reagents without requiring physical removal or extensive flushing. This chemical neutralization approach eliminates contamination risks while maintaining rapid analysis cycling, as the relaxation reagent can be introduced quickly and neutralizes contaminants in-situ

Inventive Principle:
Principle #24Intermediary (Mediator)

3Measurement precision

If a relaxation reagent is introduced to neutralize residual liquid, then the accuracy of subsequent analysis is improved, but an additional step is added to the process

Engineering Contradiction:
Improveanalysis accuracyVSAvoidprocess steps
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The introduction of the relaxation reagent is merged with the existing reagent introduction process. The relaxation reagent is delivered through the same reagent introduction mechanism that introduces the analysis reagents, and its delivery is controlled by the same control unit. This integration means no additional physical hardware or separate operational sequence is needed, adding minimal complexity while significantly improving accuracy

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach effectively neutralizes or relaxes the residual components, ensuring accurate subsequent processes, ensuring accurate subsequent processes such as analysis results are accurately addressed, achieving effective and accurate analysis by the residual reagents in the mixed liquid chamber.

Implementation Method 1

a relaxation reagent 133 into the mixed liquid chamber 110. The relaxation reagent 133 is selected based on the characteristics of the first mixed liquid 131 and relaxes the effect of the first reagent 131 remaining in the mixed liquid chamber 110

Methodology Applied
Scientific EffectDilution:

Data Source

PatentUS12631659B2Automated analyzer
Publication Date: 2026.05.19 HITACHI HIGH TECH CORP
  • US12631659B2 patent drawing
  • US12631659B2 patent drawing
  • US12631659B2 patent drawing

AI summary

To provide an automatic analyzer capable of relaxing the effect of a previously created mixed liquid when a new mixed liquid is created. An automatic analyzer according to the present disclosure: is configured so as to create a second mixed liquid after a first mixed liquid is created; and introduces a relaxation reagent to relax the effect of a first reagent remaining in a mixed liquid chamber when the second mixed liquid is created into the mixed liquid chamber on the basis of characteristics of the first mixed liquid.