Mixed Mode Microfluidic Distributor Clogging Resistance

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Solution Overview

Problem

Existing microfluidic flow distributors face challenges in achieving both minimal dispersion and resistance to clogging, with bifurcating distributors being sensitive to clogging and radially interconnected distributors performing poorly under low clogging conditions.

Innovation Solution

A mixed mode distributor design that combines bifurcating and radially interconnected elements, featuring alternating bifurcating and common channel substructures where fluid from bifurcating channels mixes in subsequent common channels, reducing clogging sensitivity while maintaining dispersion characteristics similar to bifurcating distributors.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If a bifurcating distributor is used to achieve minimal dispersion, then dispersion is reduced, but the distributor becomes very sensitive to local clogging

Engineering Contradiction:
ImprovedispersionVSAvoidclogging sensitivity
Core Design Contradiction:
Manufacturing precisionVSReliability

Solution Approach 1:

The distributor is divided into multiple levels with bifurcating channel substructures that split flow paths into segments. This segmentation allows the system to maintain the dispersion benefits of bifurcating designs while adding common channel substructures that provide alternative flow paths, reducing sensitivity to local clogging in any single segment.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The invention merges bifurcating channel substructures with common channel substructures into a hybrid architecture. The bifurcating portions provide controlled dispersion, while the common channels allow multiple flow paths to converge and provide redundancy, combining the advantages of both distributor types to resolve the contradiction between minimal dispersion and clogging resistance.

Inventive Principle:
Principle #5Merging (Combining)

2Reliability

If a radially interconnected distributor is used to improve clogging resistance, then clogging resistance is enhanced, but dispersion losses increase significantly

Engineering Contradiction:
Improveclogging resistanceVSAvoiddispersion losses
Core Design Contradiction:
ReliabilityVSManufacturing precision

Solution Approach 1:

The radially interconnected distributor is segmented into alternating bifurcating and common channel substructures. This segmentation limits the radial mixing to specific common channel regions rather than throughout the entire distributor, thereby reducing overall dispersion losses while retaining the clogging resistance benefit of radial interconnection in the common channels.

Inventive Principle:
Principle #1Segmentation

3Speed

If bifurcating distributors use velocity-matching at each bifurcation, then velocity remains constant, but channel width must increase significantly in early stages

Engineering Contradiction:
ImprovevelocityVSAvoidchannel width
Core Design Contradiction:
SpeedVSArea of stationary object

Solution Approach 1:

The channel structure is segmented into alternating bifurcating and common channel substructures. This segmentation allows the system to maintain more consistent channel widths across bifurcation levels by introducing common channels that redistribute flow, eliminating the need for progressively wider channels in early bifurcation stages while maintaining velocity control.

Inventive Principle:
Principle #1Segmentation

Data Source

PatentUS11207682B2Flow distributor
Publication Date: 2021.12.28 PHARMAFLUIDICS NV
  • US11207682B2 patent drawing
  • US11207682B2 patent drawing
  • US11207682B2 patent drawing

AI summary

A distributor is described for distributing a fluid flow from a smaller to a more broad fluid flow. It comprises a fluid input and a plurality of fluid outputs, and a channel structure in between the fluid input and the plurality of fluid outputs. The channel structure comprises alternatingly bifurcating channel substructures and common channel substructures wherein the substructures are arranged so that fluid exiting different channels from a bifurcating channel substructure mixes in a subsequent common channel substructure, and whereby fluid channels of the bifurcating channel substructure are arranged such that these do not contact the subsequent common channel substructure at the edges thereof.