Mixed Salt Oxybate Composition for Low-Sodium Hypersomnia Treatment

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Solution Overview

Problem

There is a need for effective treatments for idiopathic hypersomnia, a rare disorder characterized by severe excessive daytime sleepiness and associated challenges that current medications, such as sodium oxybate, pose significant sodium intake challenges.

Innovation Solution

A mixed salt oxybate formulation comprising calcium, sodium, potassium, and magnesium salts is administered to patients, providing therapeutic benefits while significantly reducing sodium intake compared to traditional sodium oxybate treatments.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If sodium oxybate is used to treat idiopathic hypersomnia, then excessive daytime sleepiness is reduced, but sodium intake becomes excessive

Engineering Contradiction:

Improveeffectiveness in treating excessive daytime sleepinessVSAvoidexcessive sodium intake

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameters of the oxybate formulation by replacing sodium salts with alternative metal salts (calcium, magnesium, potassium, zinc), thereby maintaining therapeutic effectiveness while reducing sodium content to below 100mg per dose

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite salt formulation combining multiple metal salts (calcium oxybate, magnesium oxybate, potassium oxybate, zinc oxybate) in specific ratios to achieve the desired therapeutic effect while minimizing sodium intake

Inventive Principle:

Principle #40Composite materials

2Reliability

If traditional sodium oxybate is administered, then therapeutic benefits are achieved, but patient safety is compromised due to high sodium content

Engineering Contradiction:

Improvetherapeutic benefitVSAvoidsafety risk from high sodium intake

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent modifies the chemical composition by substituting high-sodium formulation with low-sodium alternative metal salts, reducing sodium content from hundreds of mg to below 100mg per dose while maintaining therapeutic efficacy

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent converts the potential harm of high sodium intake into a benefit by using alternative metal salts that provide similar therapeutic effects without the adverse cardiovascular and renal effects associated with high sodium consumption

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Data Source

PatentUS12582622B2Sodium oxybate to treat idiopathic hypersomnia

Publication Date: 2026.03.24 JAZZ PHARMA IRELAND LTD

AI summary

The present disclosure relates to methods of treating idiopathic hypersomnia with oxybate, preferably sodium oxybate.