Mixed Triglyceride Composition for Butyrate Delivery and Ketone Support
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Solution Overview
Problem
Butyric acid and tributyrin have negative sensory qualities such as vomit-like, fecal, and cheesy aroma attributes, making oral administration difficult, especially in pediatric populations, and medium chain triglycerides (MCT) cause gastrointestinal intolerance at high doses, limiting ketone production.
Innovation Solution
Development of triglycerides composed of a mixture of butyrate and medium chain fatty acids (MCFAs) with improved odor and taste, providing a dietary source of butyrate and ketones without additional mineral salts, synthesized through esterification or interesterification processes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If butyric acid or tributyrin is used as a dietary source, then butyrate delivery is achieved, but negative sensory qualities (vomit-like, fecal, cheesy aroma) make oral administration difficult
Solution Approach 1:
The patent uses medium chain fatty acids (MCFAs) as intermediary components to create mixed triglycerides that mask the unpleasant sensory qualities of butyric acid while maintaining butyrate delivery functionality. The MCFA portion acts as a mediator that improves organoleptic properties without compromising the therapeutic effect.
Solution Approach 2:
The invention creates composite triglyceride molecules combining butyrate chains with medium chain fatty acid chains. This composite structure integrates the beneficial butyrate delivery function with the improved sensory properties of MCFAs, resolving the contradiction between efficacy and acceptability.
2Quantity of substance
If medium chain triglycerides (MCT) are used at high doses to produce ketones, then ketone production increases, but gastrointestinal intolerance occurs
Solution Approach 1:
The patent changes the chemical composition parameters of the triglyceride by incorporating butyrate chains alongside MCFA chains. This parameter modification allows the formulation to produce ketones effectively while reducing the gastrointestinal side effects associated with high-dose pure MCT consumption.
3Quantity of substance
If pure butyrate formulations are used, then butyrate supplementation is achieved, but additional mineral salts are introduced
Solution Approach 1:
The invention applies local quality by creating triglyceride molecules where only specific portions (the fatty acid chains) provide the desired butyrate supplementation, while the glycerol backbone and MCFA chains do not introduce unwanted mineral salts. This localized functionality achieves supplementation without contamination.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The new triglycerides offer improved organoleptic properties, allowing for increased butyrate and ketone blood levels, enhancing gastrointestinal health and treating diseases associated with low ketone levels, including neurological disorders and metabolic diseases.
Implementation Method 1
synthesized through esterification or interesterification processes
Implementation Method 2
synthesized through esterification or interesterification processes
Implementation Method 3
Under hydrolysis conditions such as those occurring during digestion, tributyrin is potentially a source of three moles of butyric acid per mole of tributyrin
Data Source
AI summary
A composition comprising a compound having the formula (1), (2), (3), (4) or combinations thereof, wherein n1, n2, n3, n4, n5 and n6 are independently 4 to 10.