Mobile Cell and Gene Processing Station for Point-of-Care Therapy
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Solution Overview
Problem
Current cell and gene therapy treatments require expensive, centralized facilities due to the need for sterile environments, leading to delays and increased costs due to remote processing of samples, which is not feasible for point-of-care locations.
Innovation Solution
A mobile cell and gene processing station that includes a patient chamber, environmental controllers, and apparatus for processing and engineering blood samples, allowing for on-site, personalized treatment at point-of-care locations with real-time adjustments based on patient data.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cell and gene therapy processing is performed in centralized facilities with sterile environments, then treatment quality and sterility are improved, but treatment time and cost increase due to remote location and sample transit
Solution Approach 1:
The centralized facility is segmented into a mobile processing station that can be deployed to point-of-care locations. The system divides the treatment process into modular components (sample collection, processing, engineering, and administration) that can be performed sequentially at the patient's location, eliminating the need to transport samples to a remote central facility while maintaining treatment quality through controlled environmental chambers.
Solution Approach 2:
The system transitions from a static centralized facility to a dynamic mobile processing station that can be transported to and deployed at various point-of-care locations. The mobile station includes environmentally controlled chambers that can be configured and operated at the patient's location, enabling real-time processing without sample transit delays.
2Reliability
If large expensive clean rooms are built for cell and gene therapy processing, then sterility and treatment quality are improved, but facility cost and complexity increase
Solution Approach 1:
The complex centralized facility infrastructure is extracted and replaced with a self-contained mobile processing station. The station includes integrated environmentally controlled chambers, processing apparatus, and support systems that can be deployed without requiring construction of large permanent clean rooms, thereby reducing facility complexity and cost while maintaining sterility through controlled environmental parameters.
Solution Approach 2:
The system changes the operational parameters from fixed facility-based processing to mobile deployable processing. The mobile station uses controlled environmental parameters (temperature, humidity, pressure) within compact chambers to achieve sterility without requiring large-scale facility infrastructure, thus reducing complexity while maintaining treatment quality.
3Ease of manufacture
If samples are transported to centralized facilities for processing, then specialized equipment and expertise are utilized, but logistical delays and costs increase
Solution Approach 1:
The mobile processing station is designed as a universal platform that can perform multiple functions (sample collection, processing, engineering, and administration) at various point-of-care locations. This multi-functional system eliminates the need for separate centralized facilities and sample transport logistics, reducing delays while maintaining specialized processing capabilities through integrated apparatus.
4Adaptability or versatility
If centralized processing centers are located remotely, then treatment specialization is improved, but accessibility and treatment speed worsen
Solution Approach 1:
The mobile processing station acts as an intermediary between the patient and the specialized treatment protocol. It brings the specialized processing capabilities directly to the point-of-care location, serving as a mobile intermediary that eliminates the need for sample transport to remote facilities while maintaining treatment specialization through integrated engineering apparatus and controlled processing environments.
Data Source
AI summary
Methods and apparatus for producing a treatment dose of engineered cells for individual patients at the point-of-care location. In some embodiments, a patient treatment system includes a mobile cell and gene processing station that provides individualized patient treatments at point-of-care locations. The cell and gene processing station may include a patient chamber configured to isolate a patient from an external environment, a first environment controller to adjust environmental parameters of the patient chamber, a processing chamber configured to isolate processing of patient cells from the external environment, a second environment controller to adjust environmental parameters of the processing chamber, a first apparatus configured to receive at least one blood sample from the patient, a second apparatus configured to process the blood sample, and a third apparatus configured to perform cell and gene engineering on the blood sample to create a treatment dose for the patient.