Mobile Zoonotic Pathogen Detection Apparatus with Integrated Air Sampling
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Solution Overview
Problem
The detection process for infectious diseases in residential and livestock areas is complex, and early warning of infectious diseases is not timely, necessitating a more efficient and automated solution for pathogen detection.
Innovation Solution
A full-automatic detection apparatus and system for zoonotic pathogens, comprising a mobile base with an air collection device, nucleic acid detection and analysis module, intelligent mobile device, and control device, which can autonomously navigate, collect samples, and perform real-time nucleic acid detection without the need for a professional laboratory, using methods like fluorescence quantification and isothermal amplification reactions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional detection methods are used for infectious diseases in residential and livestock areas, then detection can be performed, but the detection process is complex and early warning is not timely
Solution Approach 1:
The patent combines multiple detection functions (air collection, nucleic acid extraction, amplification, and detection) into a single integrated automated detection device. This merging of functions eliminates the need for separate laboratory equipment and manual operations, thereby simplifying the detection process while significantly improving detection speed and enabling timely early warning of infectious diseases.
Solution Approach 2:
The detection device performs automated operations including autonomous navigation to sampling locations, automatic air collection, automated nucleic acid extraction, and self-conducted amplification and detection. This self-service capability eliminates the need for professional laboratory personnel and complex manual procedures, reducing operational complexity while maintaining high detection productivity.
2Measurement precision
If professional nucleic acid detection laboratory is used, then accurate detection can be achieved, but the requirement for professional laboratory limits widespread use
Solution Approach 1:
The patent designs a universal detection device that can be deployed in diverse environments including residential areas, livestock farms, and other locations without requiring a professional laboratory setting. The device performs multiple functions (navigation, sampling, extraction, amplification, detection) in one unit, enabling accurate pathogen detection across various应用场景 and significantly expanding the adaptability and versatility of the detection system.
Solution Approach 2:
The portable automated detection device serves as an intermediary between field sampling locations and traditional laboratory settings. It brings laboratory-grade detection capabilities to the field through automated miniaturized systems, eliminating the need for physical transportation of samples to laboratories while maintaining detection accuracy and enabling real-time on-site analysis.
3Ease of operation
If manual detection process is used, then detailed analysis can be performed, but the process is complicated and requires professional personnel
Solution Approach 1:
The detection device autonomously performs navigation to sampling locations, automatic air collection through compressed gas delivery, automated nucleic acid extraction using magnetic bead technology, and self-conducted amplification and detection. This complete automation eliminates the need for professional personnel to perform manual operations, greatly simplifying the ease of operation while achieving a high extent of automation throughout the entire detection workflow.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables continuous and real-time monitoring of infectious pathogens, facilitating timely early warning and risk assessment, and can be widely used in farms and disease monitoring points without the requirement for a professional nucleic acid detection laboratory.
Implementation Method 1
an air compressor, configured to extract the air along with the movement of the base
Implementation Method 2
a filter membrane, configured to filter the air
Implementation Method 3
an elution instrument, configured to clean the filter membrane by using a sampling medium and collect the to-be-detected sample
Implementation Method 4
the thermal inactivation and cracking module is configured to inactivate and crack bacteria or viruses in the to-be-detected sample
Implementation Method 5
the concentration module is configured to concentrate the to-be-detected sample
Implementation Method 6
detection methods used by the at least two nucleic acid detection modules include fluorescence quantification
Implementation Method 7
loop-mediated isothermal amplification reaction, strand displacement isothermal amplification reaction, rolling loop amplification reaction
Data Source
AI summary
A full-automatic detection apparatus and system for important zoonotic pathogen, and a control method therefor. The full-automatic detection apparatus for important zoonotic pathogen includes: a base capable of moving; an air collection device, configured to collect a to-be-detected sample in air along with the movement of the base; a nucleic acid detection and analysis device, configured to detect the to-be-detected sample collected by the air collection device to determine whether an infectious pathogen exists in the to-be-detected sample; an intelligent mobile device, configured to plan and control a moving path of the base; and a control device, configured to control the intelligent mobile device to plan and control the moving path of the base and to control a sampling period of the air collection device according to a control instruction of the terminal, and transmit a detection result from the nucleic acid detection and analysis device to the terminal.