Modified Agglomerate Fillers for Consistent Oral Compound Release
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Solution Overview
Problem
Existing oral products face challenges in achieving controlled release of active compounds, particularly nicotine and cannabis extracts, due to variations in moisture content and interaction with saliva, leading to inconsistent and inefficient delivery.
Innovation Solution
The development of a modified agglomerate using a porous carrier material coated with a surface modifier, such as sugar alcohol or hydrophobic materials like corn zein, which is combined with active ingredients to form a filler that enhances controlled release when exposed to saliva.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional fillers are used in oral products, then the product structure is simple, but the release of active compounds is inconsistent and inefficient
Solution Approach 1:
The patent applies composite materials by combining porous carrier particles with surface modifiers (such as sugars, polyols, or hydrophobic materials) to create a multi-component filler system. This composite structure enables controlled release of active compounds while maintaining structural integrity, directly resolving the contradiction between release consistency and structural simplicity.
Solution Approach 2:
The patent implements local quality by applying surface modifiers specifically to the outer surfaces of porous carrier particles. This creates regions with different properties: the interior porous structure provides absorption capacity while the modified surface controls release kinetics, achieving consistent release without requiring complete restructuring of the entire filler material.
2Quantity of substance
If porous carrier material is used to increase surface area, then the absorption capacity improves, but the interaction with saliva becomes unpredictable
Solution Approach 1:
The patent applies parameter changes by modifying surface properties through coating with specific materials (sugars, polyols, hydrophobic substances) that alter the interaction characteristics with saliva. This allows the porous structure to maintain its high capacity while the surface parameters are adjusted to provide predictable, stable interaction with oral fluids.
Solution Approach 2:
The surface modifiers act as intermediaries between the porous carrier material and saliva. These coating materials mediate the interaction, providing a controlled interface that prevents unpredictable direct contact between the porous structure and saliva, thereby stabilizing the release behavior while preserving absorption capacity.
3Reliability
If hydrophobic materials are applied to the surface, then the controlled release is enhanced, but the manufacturing process becomes more complex
Solution Approach 1:
The patent utilizes porous carrier materials as the base structure, which inherently provide controlled release capabilities through their internal pore networks. This reduces the reliance on complex hydrophobic surface coatings, simplifying the manufacturing process while maintaining reliable controlled release performance.
4Quantity of substance
If the filler is highly porous to increase surface area, then the active ingredient loading increases, but the structural integrity decreases
Solution Approach 1:
The patent creates composite agglomerates by combining porous particles with binding agents and surface modifiers. This composite approach allows the porous structure to maintain high surface area for ingredient loading while the composite nature provides the structural integrity needed to prevent disintegration during oral processing and use.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The modified agglomerate facilitates consistent and enhanced release of active ingredients, improving the delivery efficiency and stability of nicotine and cannabis compounds in oral products.
Implementation Method 1
The surface modifier coats at least a portion of a surface of the agglomerate, is in pores of the agglomerate, or both coats at least a portion of the surface of the agglomerate and is in pores of the agglomerate
Implementation Method 2
The surface modifier includes a sugar alcohol or a hydrophobic material
Data Source
AI summary
An oral product includes a filler and an active ingredient. The filler includes a modified agglomerate and a surface modifier. The modified agglomerate includes a porous carrier. The surface modifier coats at least a portion of a surface of the agglomerate, is in pores of the agglomerate, or both coats at least a portion of the surface of the agglomerate and is in pores of the agglomerate. The surface modifier includes a sugar alcohol or a hydrophobic material. The active ingredient is admixed with the filler.