Genetically Modified Bacteria for Skin Microbiome Balance
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Solution Overview
Problem
Current methods for enhancing skin health fail to effectively address the balance of the skin microbiome, particularly in aging individuals, leading to increased susceptibility to infections and diseases due to the aging immune system's reduced robustness.
Innovation Solution
The use of human-specific bacteria strains modified via CRISPR-Cas9 and Cpf1 systems to alter their native pathogenicity, administered topically to promote beneficial microbial secretions and maintain a healthy skin microbiome, including the application of prebiotics and specific bacteria strains like Propionibacterium and Lactobacillus to balance the skin's microbial population.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional skin health enhancement methods are used, then general skin care is provided, but the skin microbiome balance is not effectively addressed
Solution Approach 1:
The patent modifies bacterial strains through genetic engineering to alter their pathogenicity parameters and enhance their ability to produce beneficial secretions. This allows the microbiome to be actively adjusted rather than passively maintained, resolving the contradiction between general skin health and specific microbiome balance
Solution Approach 2:
The patent introduces modified bacteria as intermediary organisms that mediate between the host skin and the microbiome environment. These engineered bacteria act as living mediators that actively maintain microbiome balance while promoting overall skin health, addressing both aspects simultaneously
2Reliability
If the immune system's robustness decreases due to aging, then natural defense capability is reduced, but susceptibility to infections increases
Solution Approach 1:
The patent converts potentially harmful pathogenic bacteria into beneficial organisms by genetically modifying them to reduce pathogenicity while enhancing protective secretions. This transforms the harm of aging-induced immune decline into an opportunity to use engineered bacteria as protective agents that actively combat infections
Solution Approach 2:
The patent applies modified bacteria prophylactically to the skin before infections can occur. By establishing a population of engineered protective bacteria in advance, the skin gains enhanced defense capabilities against future infections, compensating for age-related immune weakening
Data Source
AI summary
Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome.