Modified Clay–Biphenol Antimicrobial Compositions for Oral Biofilm Control
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Solution Overview
Problem
There is a need for antimicrobial compositions with improved antimicrobial activity, particularly for use in personal care products such as oral care compositions, to effectively prevent and treat conditions like oral biofilm, plaque, gum diseases, and halitosis.
Innovation Solution
The composition combines modified clay particles with an antimicrobial compound, specifically quaternary ammonium material like cetylpyridinium chloride (CPC), and a biphenol component, such as honokiol and magnolol, to enhance antimicrobial efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antimicrobial components are used in personal care compositions, then basic antimicrobial activity is provided, but the antimicrobial efficacy is insufficient to effectively prevent and treat oral biofilm, plaque, and gum diseases
Solution Approach 1:
The patent combines modified clay particles with quaternary ammonium compounds and biphenol compounds to create a composite antimicrobial system. This composite approach integrates multiple active ingredients with different mechanisms of action, providing synergistic antimicrobial activity that effectively targets oral biofilm, plaque, and gum diseases while maintaining stability in personal care compositions.
2Reliability
If higher concentrations of single antimicrobial compounds are used, then antimicrobial activity increases, but the composition complexity and potential irritation increase
Solution Approach 1:
The patent divides the antimicrobial function into multiple segments: modified clay particles as carriers, quaternary ammonium compounds for membrane disruption, and biphenol compounds for additional antimicrobial action. This segmentation allows each component to contribute differently to the overall antimicrobial effect, reducing the need for high concentrations of a single compound and thereby lowering composition complexity and potential irritation.
3Reliability
If modified clay particles with quaternary ammonium compounds are used, then antimicrobial activity is enhanced, but the cost and manufacturing complexity increase
Solution Approach 1:
The patent incorporates quaternary ammonium compounds into the clay particle structure during the manufacturing process, creating pre-functionalized modified clay particles. This preliminary action of impregnating or coating the clay particles with antimicrobial agents during production simplifies subsequent formulation steps, as the clay particles arrive at the final formulation stage already equipped with their antimicrobial function, thereby reducing overall manufacturing complexity despite the enhanced antimicrobial activity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of modified clay and biphenol compounds demonstrates improved antimicrobial activity, effectively reducing oral biofilm, malodor, and tooth discoloration, while providing therapeutic benefits for oral health and cosmetic improvements.
Implementation Method 1
at least one orally acceptable antimicrobial compound selected from a quaternary ammonium material wherein the at least one antimicrobial compound is attached to the coordinating cation on an external surface plane of the clay particle
Data Source
AI summary
The present invention is in the field of antimicrobial compositions, e.g. for personal care. In particular, the invention relates to antimicrobial compositions for oral care, such as toothpastes, comprising antimicrobial particles and biphenol. Accordingly, the present invention relates to antimicrobial compositions comprising a modified clay particle, the particle comprising an antimicrobial compound and a clay particle, and at least one biphenol compound. The invention further relates to the uses and methods of the antimicrobial compositions of the invention.