Modified Pyrrole Derivatives for Broad-Spectrum Pest Control
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Solution Overview
Problem
Current pyrrole derivatives for pest control lack efficacy and specificity, particularly in insecticidal, acaricidal, molluscicidal, and nematicidal applications, with existing compounds often requiring higher application rates and having limited spectrum of activity.
Innovation Solution
Development of novel pyrrole derivatives with specific structural modifications, such as those described in formula (I), which include various substituents and functional groups, enhancing their insecticidal, acaricidal, molluscicidal, and nematicidal properties, allowing for lower application rates and broader pest control efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If existing pyrrole derivatives are used for pest control, then they provide basic pesticidal activity, but they require higher application rates and have limited spectrum of activity
Solution Approach 1:
The patent applies parameter changes by systematically modifying the chemical structure of pyrrole derivatives through various substitutions at different positions (R1, Q, L, T, R2, R3, Z1-Z4 groups). These structural parameter changes result in compounds with enhanced pesticidal activity and broader spectrum of action against multiple pest types including insects, acarines, molluscs, and nematodes, thereby reducing the required application rates while expanding adaptability
Solution Approach 2:
The invention creates composite molecular structures by combining the pyrrole core with diverse functional groups and substituents (halogen, cyano, alkoxy, carbonyl, heterocyclic groups). This composite approach generates a series of derivative compounds with varied and enhanced biological activities, achieving both reduced application rates and expanded pest control spectrum simultaneously
2Reliability
If existing pyrrole derivatives are used, then they provide pesticidal activity, but they lack potency and specificity
Solution Approach 1:
The patent employs local quality by introducing specific substituents at particular positions on the pyrrole ring structure. Each substitution (R1 at position 1, Q at position 2, L and T groups, and Z1-Z4 halogen/cyano/alkyl groups) creates localized chemical modifications that enhance binding affinity and specificity to pest target sites, thereby improving potency and reducing required application rates
3Adaptability or versatility
If higher application rates are used to achieve effective pest control, then broader pest coverage is obtained, but tolerance by warm-blooded species, fish, and plants may be reduced
Solution Approach 1:
The structural modifications in the pyrrole derivatives (varying R groups, L, T, and Z substituents) optimize the compounds' biological profile by enhancing pest-specific activity while maintaining or improving safety margins. The patent demonstrates that these parameter changes achieve broad-spectrum pest control at lower application rates, thereby preserving tolerance in non-target organisms including warm-blooded species, fish, and plants
Data Source
AI summary
Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.