Modified-Release Amino Acid Composition for Pressure Ulcers
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Patients with pressure ulcers and contraindications for a high-protein diet due to renal failure face deficiencies in specific amino acids like tryptophan, histidine, and threonine, which are not adequately addressed by existing high-protein supplements, leading to limited efficacy in wound healing.
Innovation Solution
A modified-release oral nutritional composition containing alanine, histidine, threonine, and tryptophan, or L-carnosine as a source of alanine and histidine, with a controlled and sustained release in the gastrointestinal tract, to address the amino acid deficiencies.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high-protein nutritional compositions are administered to patients with pressure ulcers, then wound healing is improved, but renal failure is exacerbated
Solution Approach 1:
The high-protein diet is segmented into individual amino acid components. Instead of administering complete protein sources that burden the kidneys, the invention provides specific amino acids (arginine, cysteine, glutamine, lysine, methionine, threonine, tryptophan, and/or valine) that are deficient in pressure ulcer patients, allowing targeted supplementation without the metabolic load of full protein digestion and excretion.
Solution Approach 2:
The nutritional composition is tailored to address local deficiencies in amino acids rather than providing a general high-protein formula. The invention identifies specific amino acids that are depleted in pressure ulcer patients and formulates the composition to replenish only those deficient components, optimizing healing support while minimizing renal stress.
2Reliability
If high-protein dietary supplements are administered to patients without malnutrition signs, then the treatment remains limited in efficacy, but the renal burden increases
Solution Approach 1:
Rather than administering complete high-protein supplements that exceed the needs of non-malnourished patients, the invention applies partial action by providing only the specific amino acids that show deficiency markers in pressure ulcer patients. This targeted approach avoids unnecessary protein load while still addressing the specific metabolic demands of wound healing.
Solution Approach 2:
The invention changes the parameters of nutritional supplementation from general high-protein formulas to specific amino acid compositions based on measured deficiency levels. By adjusting the composition to match actual patient needs rather than applying a standard high-protein protocol, the treatment becomes more effective for the specific condition while reducing unnecessary renal burden.
Data Source
AI summary
The invention relates to a nutritional composition, preferably in a modified release form, for oral use in supplementing patients with amino acids, in order to treat and/or prevent pressure ulcer formation, which comprises amino acids: alanine, histidine, threonine and tryptophan, more preferably L- camosine as a source of alanine and histidine, and threonine and tryptophan as an active ingredient; wherein preferably the nutritional composition is for use in supplementation of patients with amino acids in order to treat and/or prevent pressure ulcer formation in patients with contraindications for a high-protein diet.