Modular Assay Pod Architecture for Portable Multi-Sample Testing
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Solution Overview
Problem
Existing portable testing devices for biological samples face issues such as contamination, insufficient sample collection, sample unsuitability, degradation, and limited sample capacity due to size constraints, as well as rapid obsolescence of components and user interface challenges.
Innovation Solution
A modular portable testing device with a head unit and removably coupled pod units, incorporating a modified tablet for user interface and heat dissipation, and pod units for assay processing, allowing scalable and simultaneous testing of multiple samples with isothermal amplification processes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Weight of moving object
If portable testing devices are made small for easy transport, then portability is improved, but the number of biological samples that can be tested at one time is limited
Solution Approach 1:
The device is divided into a head unit and multiple detachable pod units. Each pod unit can independently hold and process sample cartridges, allowing the system to scale from single-sample to multi-sample testing by simply attaching additional pods. This segmentation resolves the contradiction by maintaining compact individual units while enabling expanded total capacity when needed.
Solution Approach 2:
The head unit is designed with universal coupling mechanisms that can interface with multiple types of pod units. The system can handle different sample types (biological, chemical, environmental) and run various assay protocols through the same core processing unit, making the device versatile across different testing scenarios without requiring separate specialized equipment.
2Adaptability or versatility
If multiple components are integrated into portable testing devices, then functionality is improved, but components quickly become obsolete due to rapid developments in processing units and user interface features
Solution Approach 1:
By separating the device into a permanent head unit and replaceable pod units, the system allows the core processing architecture to remain stable while only the assay-specific components in the pods need updating. This reduces overall obsolescence risk as the head unit's fundamental processing capabilities remain valid for extended periods.
Solution Approach 2:
The system accommodates technological advances by allowing parameter changes in the pod units (such as updated sensors, reagent formulations, or processing protocols) without requiring changes to the head unit's core architecture. This enables gradual evolution of capabilities while maintaining compatibility with existing infrastructure.
3Measurement precision
If biological samples are collected in the field and transported to the laboratory, then comprehensive testing can be performed, but the sample can be contaminated or degrade before testing
Solution Approach 1:
The device enables preliminary testing actions to be performed immediately at the collection site. Sample preparation, processing, and analysis can all occur in-situ before any contamination or degradation can occur during transport. The modular design allows all necessary components (reagents, processing chambers, detection systems) to be present and operational at the point of collection.
Solution Approach 2:
The pod units serve as intermediary sealed containers that protect samples from environmental contamination during field collection and transport. The pods create a controlled environment between the sample and external contaminants, maintaining sample integrity until testing is complete.
4Device complexity
If a single testing device is used, then device simplicity is maintained, but the ability to run different protocols simultaneously is limited
Solution Approach 1:
Multiple independent pod units can be attached to a single head unit, with each pod capable of running different assay protocols simultaneously. This segmentation allows parallel processing of multiple samples with different testing requirements while maintaining a single integrated control system in the head unit for coordinated operation.
Solution Approach 2:
The system enables continuous productive action by allowing multiple assays to run in parallel across different pod units. While one pod completes its protocol, another can already be processing the next sample, eliminating idle time and maximizing the utilization of the head unit's processing capabilities across multiple concurrent operations.
Data Source
AI summary
A portable testing device that includes a head unit with a user interface and modular pod units that are attachable to the head unit and include componentry for performing assay testing of biological samples received in each respective pod unit. The head unit can utilize a user interface and optical reader of a modified tablet device incorporated within the housing of the head unit. The pod units can utilize a well block for receiving an array of sample tubes and an optical assembly having LEDS, a multiple bandpass filters, and a single ADC board with photodiodes that are disposed on both sides or only on one side of the receptacle of the well block.