Modular Assay System Vertical Tower Design
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Solution Overview
Problem
Current assay devices are too large and cumbersome for remote or point-of-care analysis, making it difficult to provide timely processing of biological samples, and there is a need for a portable and versatile system that can handle high volumes of samples effectively.
Innovation Solution
A modular assay system comprising vertically connected towers with assay units, each equipped with localized heating means, optical detectors, and unique serial identifiers, allowing for efficient sample processing and data encoding using color patches and thermochromic coatings for temperature control and data integrity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a single large assay device is used for high-volume sample processing, then productivity is improved, but device size and portability deteriorate
Solution Approach 1:
The system is divided into multiple discrete assay units that can be vertically stacked to form towers. Each unit is a self-contained module with its own assay device, allowing the system to be configured in different sizes based on throughput requirements while maintaining portability of individual units.
Solution Approach 2:
The system transitions from horizontal expansion (single large device) to vertical expansion (stacked towers). Multiple assay units are arranged vertically and connected through a robotic arm that can access all levels, enabling high throughput without increasing the horizontal footprint.
2Ease of operation
If multiple discrete assay devices are used for portability, then ease of operation is improved, but productivity deteriorates
Solution Approach 1:
Multiple portable assay units are merged into a integrated tower system with a shared robotic arm and control system. The robotic arm automatically transfers samples between units, combining the portability of individual units with the high throughput of a multi-device system.
Solution Approach 2:
The robotic arm and control system serve multiple functions across different assay units, enabling a single portable tower to perform high-volume processing that would otherwise require multiple separate devices. Each tower can be independently ported while maintaining multi-unit functionality.
3Area of stationary object
If assay units are vertically stacked to save space, then device complexity is reduced, but locating and alignment precision deteriorates
Solution Approach 1:
Mechanical alignment features (locating arms and stop lugs) are used to establish precise geometric relationships between vertically stacked units. These mechanical features ensure consistent positioning without requiring complex adjustment mechanisms, maintaining alignment precision while simplifying the overall system.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables portable, efficient, and high-throughput biological assaying with precise temperature control and data integrity, facilitating timely analysis and preventing mismatched results through secure and compact data encoding.
Implementation Method 1
Localised heat is achieved by means of induction and/or resistive heating means
Implementation Method 2
Localised heat is achieved by means of induction and/or resistive heating means
Implementation Method 3
Each assay unit may comprise an optical detector for use in an assay. The optical detector may be capable of determining colour
Implementation Method 4
The means for determining temperature may comprise a thermochromic coating. The thermochromic coating may determine that the temperature within a specified area has reached the desired temperature
Data Source
Figure 1a~1b
Figure 2
Figure 3a~3b
AI summary
A system for conducting an assay comprises a power source (16), a controller (13) for controlling the assay and a plurality of assay units (14) operatively connected to one another such that the controller can communicate with the assay units and the system is capable of conducting the assay. An assay device comprises a substantially circular body (24) having a plurality of chambers in fluid connection such that fluid can pass between said chambers and a central hub (200) having a sample inlet (202) disposed therein for receiving a sample.